Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy

1. Front Matter

   Pages i-xxi

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2. Translation of Optical Imaging Techniques

   • Dale Jonathan Waterhouse

   Pages 1-16

3. Flexible Endoscopy: Early Detection of Dysplasia in Barrett’s Oesophagus

   • Dale Jonathan Waterhouse

   Pages 17-42

4. Flexible Endoscopy: Device Architecture

   • Dale Jonathan Waterhouse

   Pages 43-73

5. Flexible Endoscopy: Optical Molecular Imaging

   • Dale Jonathan Waterhouse

   Pages 75-100

6. Flexible Endoscopy: Multispectral Imaging

   • Dale Jonathan Waterhouse

   Pages 101-126

7. Rigid Endoscopy for Intraoperative Imaging of Pituitary Adenoma

   • Dale Jonathan Waterhouse

   Pages 127-138

8. Conclusions and Outlook

   • Dale Jonathan Waterhouse

   Pages 139-142

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

• Optical Imaging of Cancer
• Multispectral Endoscopy
• Multispectral Imaging of Cancer
• Clinical Translation of Optical Imaging Techniques
• Advanced Endoscopic Imaging in Barrett's Oesophagus
• Advanced Endoscopic Imaging in Pituitary Surgery
• Early Detection of Oesophageal Cancer
• Intraoperative Imaging of Pituitary Adenoma
• Diagnostic Radiology

• Department of Physics and Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK

  Dale Jonathan Waterhouse

Dale J. Waterhouse received first class B.A. and M.Sci. degrees in Natural Sciences from the University of Cambridge in 2014. He recieved a Ph.D.degree in Physics from the University of Cambridge in 2018, where his thesis work focused on development of novel endoscopic imaging techniques. This culminated in the development of two clinically translatable multispectral endoscopes, one for early detection of cancer in the oesophagus, and the other for delineation of cancer in surgical resection of pituitary adenoma. In 2018 he was awarded an EPSRC Doctoral Fellowship, allowing him to continue this work, deploying these devices in first in human clinical trials.

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