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Brain and Human Body Modeling

Computational Human Modeling at EMBC 2018

  • Describes construction and application of computational human models including anatomically detailed and subject specific models
  • Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations
  • Includes a survey of modern applications for which computational human models are critical
  • Describes cellular-level interactions between the human body and electromagnetic fields

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xi
  2. Human Body Models for Non-invasive Stimulation

    1. Front Matter

      Pages 1-1
    2. SimNIBS 2.1: A Comprehensive Pipeline for Individualized Electric Field Modelling for Transcranial Brain Stimulation

      • Guilherme B. Saturnino, Oula Puonti, Jesper D. Nielsen, Daria Antonenko, Kristoffer H. Madsen, Axel Thielscher
      Pages 3-25Open Access
    3. Finite Element Modelling Framework for Electroconvulsive Therapy and Other Transcranial Stimulations

      • Azam Ahmad Bakir, Siwei Bai, Nigel H. Lovell, Donel Martin, Colleen Loo, Socrates Dokos
      Pages 27-47Open Access
    4. Estimates of Peak Electric Fields Induced by Transcranial Magnetic Stimulation in Pregnant Women as Patients or Operators Using an FEM Full-Body Model

      • Janakinadh Yanamadala, Raunak Borwankar, Sergey Makarov, Alvaro Pascual-Leone
      Pages 49-73Open Access
    5. Electric Field Modeling for Transcranial Magnetic Stimulation and Electroconvulsive Therapy

      • Zhi-De Deng, Conor Liston, Faith M. Gunning, Marc J. Dubin, Egill Axfjörð Fridgeirsson, Joseph Lilien et al.
      Pages 75-84Open Access
    6. Design and Analysis of a Whole-Body Noncontact Electromagnetic Subthreshold Stimulation Device with Field Modulation Targeting Nonspecific Neuropathic Pain

      • Sergey Makarov, Gene Bogdanov, Gregory Noetscher, William Appleyard, Reinhold Ludwig, Juho Joutsa et al.
      Pages 85-123Open Access
  3. Tumor Treating Fields (TTFs)

    1. Front Matter

      Pages 125-125
    2. Simulating the Effect of 200 kHz AC Electric Fields on Tumour Cell Structures to Uncover the Mechanism of a Cancer Therapy

      • Kristen W. Carlson, Jack A. Tuszynski, Socrates Dokos, Nirmal Paudel, Ze’ev Bomzon
      Pages 127-137Open Access
    3. The Bioelectric Circuitry of the Cell

      • Jack A. Tuszynski
      Pages 195-208Open Access
  4. Electromagnetic Safety

    1. Front Matter

      Pages 209-209
    2. Brain Haemorrhage Detection Through SVM Classification of Electrical Impedance Tomography Measurements

      • Barry McDermott, Eoghan Dunne, Martin O’Halloran, Emily Porter, Adam Santorelli
      Pages 211-244Open Access
    3. Patient-Specific RF Safety Assessment in MRI: Progress in Creating Surface-Based Human Head and Shoulder Models

      • Mikhail Kozlov, Benjamin Kalloch, Marc Horner, Pierre-Louis Bazin, Nikolaus Weiskopf, Harald E. Möller
      Pages 245-282Open Access
    4. Calculation of MRI RF-Induced Voltages for Implanted Medical Devices Using Computational Human Models

      • James E. Brown, Rui Qiang, Paul J. Stadnik, Larry J. Stotts, Jeffrey A. Von Arx
      Pages 283-294Open Access
    5. Dose Coefficients for Use in Rapid Dose Estimation in Industrial Radiography Accidents

      • Haegin Han, Yeon Soo Yeom, Chansoo Choi, Hanjin Lee, Bangho Shin, Xujia Zhang et al.
      Pages 295-304Open Access
    6. Effect of Non-parallel Applicator Insertion on 2.45 GHz Microwave Ablation Zone Size and Shape

      • Austin W. White, Dwight D. Day, Punit Prakash
      Pages 305-314Open Access

About this book

This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner.

  • Describes construction and application of computational human models including anatomically detailed and subject specific models;
  • Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations;
  • Includes a survey of modern applications for which computational human models are critical;
  • Describes cellular-level interactions between the human body and electromagnetic fields.

Editors and Affiliations

  • Massachusetts General Hospital, Boston, USA

    Sergey Makarov

  • ANSYS, Inc., Evanston, USA

    Marc Horner

  • Worcester Polytechnic Institute, Worcester, USA

    Gregory Noetscher

About the editors

Sergey Makarov is a full professor of Electrical and Computer Engineering at Worcester Polytechnic Institute, having taught a wide variety of graduate and undergraduate classes and established a very active record of academic and research advising. His formal educational background is in applied mathematics and electromagnetics but since moving to WPI in 1998, his research field has been shifted to analysis and design with virtual human models including image segmentation, surface extraction, and CAD model generation. Dr. Makarov has published about 150 conference and journal papers, three books, and he holds active 6 patents with four other pending. He has received numerous departmental and institute-wide awards for his teaching, advising, and service and is a Senior Member of the IEEE, participating in or chairing committees related to electromagnetic safety and education. In 2009, Dr. Makarov founded NEVA Electromagnetics, LLC, serving customers in need of multi-tissue virtual human models generated from biomedical image datasets for electromagnetic and mechanical simulation studies, body-worn antenna designs, and biomedical sensor designs for many applications. Dr. Makarov is also a member of the Research Staff at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital, conducting investigative studies in non-invasive brain stimulation technologies that utilize many of his computational human phantoms.

Marc Horner is the technical lead for healthcare applications at ANSYS, Inc. Marc joined ANSYS after earning his Ph.D. in Chemical Engineering from Northwestern University in 2001. Marc began by providing support and professional services for biomedical and pharmaceutical industry clients before transitioning to a healthcare business and technology development role. Marc is Vice Chair of the ASME V&V40 Sub-Committee - which is establishing V&V best practices for the medical device industry, and the ASME V&V Standards Committee - who oversee the creation of best practices and general guidance on V&V for CM&S. Marc is also an Associate Editor of the ASME Journal of Verification, Validation, and Uncertainty Quantification. Lastly, Marc is an Executive Committee Member of the IMAG/MSM Credible Practice of Modeling & Simulation in Healthcare project who aim to establish a task-oriented collaborative platform that outlines credible practices of simulation-based medicine.

Gregory Noetscher is a senior research electrical engineer with the US Army at the Natick Soldier Research, Development and Engineering Center in Natick, MA, having worked on and coordinated a variety of experimental and simulation projects related to precision guided cargo airdrop since 2003. His research interests since 2009 have also included the construction and application of highly non-homogeneous human body phantoms.  Dr. Noetscher also serves as a Research Scientist at Worcester Polytechnic Institute, participating and directingresearch on human phantom creation and application. He is a member of the IEEE and has published over 50 conference and journal articles, one textbook, and holds two active patents with three pending.

Bibliographic Information

  • Book Title: Brain and Human Body Modeling

  • Book Subtitle: Computational Human Modeling at EMBC 2018

  • Editors: Sergey Makarov, Marc Horner, Gregory Noetscher

  • DOI: https://doi.org/10.1007/978-3-030-21293-3

  • Publisher: Springer Cham

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2019

  • Hardcover ISBN: 978-3-030-21292-6Published: 05 September 2019

  • Softcover ISBN: 978-3-030-21295-7Published: 05 September 2020

  • eBook ISBN: 978-3-030-21293-3Published: 27 August 2019

  • Edition Number: 1

  • Number of Pages: XI, 402

  • Number of Illustrations: 27 b/w illustrations, 148 illustrations in colour

  • Topics: Biomedical Engineering and Bioengineering, Circuits and Systems, Microwaves, RF and Optical Engineering

Buy it now

Buying options

Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 59.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access