MHC Class-I Loss and Cancer Immune Escape

1. Front Matter

   Pages i-x

   PDF

2. Introduction

   • Federico Garrido

   Pages 1-14

3. MHC/HLA Class I Loss in Cancer Cells

   • Federico Garrido

   Pages 15-78

4. HLA Class-I Expression and Cancer Immunotherapy

   • Federico Garrido

   Pages 79-90

5. HLA Class-II Expression in Human Tumors

   • Federico Garrido

   Pages 91-95

6. Back Matter

   Pages 97-101

   PDF

 

This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”.

Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism.

Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast…ect. as well as melanoma and lymphoma.

This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in “Tumor Immunology”.   

• tumor
• immune escape
• T lymphocytes
• HLA
• cancer immunotherapy

• Departamento de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Facultad de Medicina, Universidad de Granada, Granada, Spain

  Federico Garrido

Prof. Federico Garrido is Professor of Immunology at the University of Granada Medical School and head of the Dept. of Clinical Analysis & Immunology at the Hospital Universitario Virgen de las Nieves, Granada, Spain. After obtaining his MD and PhD degrees from the University of Granada in 1974, Prof. Garrido went on as a postdoctoral fellow at the laboratory of Dr. Hilliard Festenstein at the London Hospital Medical College in London, investigating the immunogenetics of the MHC (H-2) system by typing mouse tumour cells for H-2 expression. After returning to Granada in 1981 he continued his research on HLA typing of human tumour tissues. Prof. Garridos research focuses on the expression of HLA antigens in tumours and the role that these molecules play on tumour evasion from the immune system.

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