Overview
- Provides the reader with a specializd vantage point from which to view the interrelatedness of various general systems of science
- Teaches microbiology, genetics, evolution, immunology as well as pharmaceutical manufacturing control including a view of the regulatory aspects
- Shows how endotoxins presents a unique vantage of a long view of life as a struggle against prokaryotic invaders and can be seen as shaping the evolving genetics and survival mechanisms of multicellular life-forms
- Presents the most up-to-date and thorough treatment of the subject as well as a host of interrelated topics written by a host of international experts and pioneers of industry
- Includes access to thorough literaure review links on the books' sister website
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Table of contents (23 chapters)
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Front Matter
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Pharma
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Front Matter
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Limulus
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Front Matter
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Limulus
Keywords
About this book
Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma).
Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated.
Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems
Editors: Kevin L. Williams
DOI: https://doi.org/10.1007/978-3-030-17148-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-17147-6Published: 07 August 2019
Softcover ISBN: 978-3-030-17150-6Published: 15 August 2020
eBook ISBN: 978-3-030-17148-3Published: 24 July 2019
Edition Number: 1
Number of Pages: XI, 869
Number of Illustrations: 78 b/w illustrations, 349 illustrations in colour
Topics: Pharmaceutical Sciences/Technology, Medical Microbiology