Overview
- Editors:
-
-
Ahmad M. Khalil
-
Case Western Reserve University School of Medicine, Cleveland, USA
Focuses on the recently discovered, and less understood, class of long non-coding RNAs
Discusses new concepts and novel approaches to studying lncRNAs
Additional expert authors in the field covering novel technologies
Access this book
Other ways to access
Table of contents (7 chapters)
-
-
-
- Sindy Zander, Roland Jacob, Tony Gutschner
Pages 35-63
-
- Alina Naveed, Ellen Fortini, Ruohan Li, Archa H. Fox
Pages 65-84
-
- Ligia I. Torsin, Mihnea P. Dragomir, George A. Calin
Pages 85-113
-
- Piyush Joshi, Ranjan J. Perera
Pages 115-126
-
- Melanie Winkle, Agnieszka Dzikiewicz-Krawczyk, Joost Kluiver, Anke van den Berg
Pages 127-149
-
- Viorel Simion, Stefan Haemmig, Mark W. Feinberg
Pages 151-179
-
Back Matter
Pages 181-187
About this book
This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.
Editors and Affiliations
-
Case Western Reserve University School of Medicine, Cleveland, USA
Ahmad M. Khalil
About the editor
Ahmad Khalil earned his PhD at the University of Florida School of Medicine where he discovered key epigenetic mechanisms that regulate gene expression during mammalian meiosis. Subsequently, he joined the Scripps Research Institute as a postdoctoral fellow (2006-2008) and studied the role of long non-coding RNAs in neurological disorders. In 2008, Dr Khalil moved to Harvard Medical School and the Broad Institute where he played a key role in discovering long intergenic non-coding (linc)RNAs in human cells, and demonstrated that lincRNAs play critical roles in epigenetic regulation of gene expression. In 2010, Dr Khalil joined the faculty at CWRU and his lab continues to study the role of lincRNAs in human health and disease.
