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Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

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  • © 2019

Overview

Editors:
  1. Jun Chen

    1. Department of Neurology, University of Pittsburgh, Pittsburgh, USA

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  2. Jian Wang

    1. Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, USA

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  3. Ling Wei

    1. Departments of Anesthesiology and Neurology, Emory University School of Medicine, Atlanta, USA

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  4. John H. Zhang

    1. Department of Physiology, Loma Linda University School of Medicine, Loma Linda, USA

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  • Comprehensive overview of studies of intranasal delivery
  • Expected to have great impact on the field of translational stroke research
  • Useful for researchers, physicians, and drug developers?

Part of the book series: Springer Series in Translational Stroke Research (SSTSR)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
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  2. Transnasal Induction of Therapeutic Hypothermia for Neuroprotection

    • Raghuram Chava, Harikrishna Tandri
    Pages 1-7

  3. Hypoxia-Primed Stem Cell Transplantation in Stroke

    • Zheng Zachory Wei, James Ya Zhang, Ling Wei
    Pages 9-26

  4. Therapeutic Potential of Intranasal Drug Delivery in Preclinical Studies of Ischemic Stroke and Intracerebral Hemorrhage

    • Qian Li, Claire F. Levine, Jian Wang
    Pages 27-42

  5. Intranasal Drug Delivery After Intracerebral Hemorrhage

    • Jing Chen-Roetling, Raymond F. Regan
    Pages 43-55

  6. Intranasal Treatment in Subarachnoid Hemorrhage

    • Basak Caner
    Pages 57-64

  7. Intranasal Delivery of Therapeutic Peptides for Treatment of Ischemic Brain Injury

    • Tingting Huang, Amanda Smith, Jun Chen, Peiying Li
    Pages 65-73

  8. Intranasal Delivering Method in the Treatment of Ischemic Stroke

    • Chunhua Chen, Mengqin Zhang, Yejun Wu, Changman Zhou, Renyu Liu
    Pages 75-89

  9. Intranasal Delivery of Drugs for Ischemic Stroke Treatment: Targeting IL-17A

    • Yun Lin, Jiancheng Zhang, Jian Wang
    Pages 91-99

  10. Intranasal tPA Application for Axonal Remodeling in Rodent Stroke and Traumatic Brain Injury Models

    • Zhongwu Liu, Ye Xiong, Michael Chopp
    Pages 101-115

  11. Therapeutic Intranasal Delivery for Alzheimer’s Disease

    • Xinxin Wang, Fangxia Guan
    Pages 117-133

  12. Intranasal Medication Delivery in Children for Brain Disorders

    • Gang Zhang, Myles R. McCrary, Ling Wei
    Pages 135-147

  13. Back Matter

    Pages 149-153
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Keywords

About this book

The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer's, Parkinson's, and others.​

Editors and Affiliations

  • Department of Neurology, University of Pittsburgh, Pittsburgh, USA

    Jun Chen

  • Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, USA

    Jian Wang

  • Departments of Anesthesiology and Neurology, Emory University School of Medicine, Atlanta, USA

    Ling Wei

  • Department of Physiology, Loma Linda University School of Medicine, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

  • Editors: Jun Chen, Jian Wang, Ling Wei, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-3-030-16715-8

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-16713-4Published: 17 June 2019

  • eBook ISBN: 978-3-030-16715-8Published: 03 June 2019

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 1

  • Number of Pages: VI, 153

  • Number of Illustrations: 3 b/w illustrations, 8 illustrations in colour

  • Topics: Neurosciences, Neurology

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