Editors:
- Provides new insights into activity-based protein profiling (ABPP), which uses chemical probes to profile the functional state of enzymes in native biological systems
- Focuses on the application of ABPP methodologies to processes relevant to microbiology and immunology
- Helps readers identify the posttranslational regulatory mechanisms that modulate protein function
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 420)
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Table of contents (16 chapters)
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Front Matter
About this book
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Editors and Affiliations
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Department of Chemistry, The Scripps Research Institute, La Jolla, USA
Benjamin F. Cravatt
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Department of Chemistry, University of Virginia, Charlottesville, USA
Ku-Lung Hsu
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Department of Chemistry, Boston College, Chestnut Hill, USA
Eranthie Weerapana
About the editors
Benjamin F. Cravatt, Ph.D.
Department of Chemistry
The Scripps Research Institute
La Jolla, CA, USA
cravatt@scripps.edu
Ku-Lung Hsu Ph.D.
University of Virginia School of Medicine
Department of Chemistry
Charlottesville, VA, USA
kh4ch@virginia.edu
Eranthie Weerapana Ph.D.
Boston College
Merkert Chemistry
Chestnut Hill, MA, USA
eranthie@bc.edu
Bibliographic Information
Book Title: Activity-Based Protein Profiling
Editors: Benjamin F. Cravatt, Ku-Lung Hsu, Eranthie Weerapana
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-030-11143-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-11142-7Published: 07 February 2019
eBook ISBN: 978-3-030-11143-4Published: 25 January 2019
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: X, 417
Number of Illustrations: 45 b/w illustrations, 70 illustrations in colour
Topics: Immunology, Medical Microbiology, Virology