Advances in Heart Valve Biomechanics

1. Front Matter

   Pages i-xxv

   PDF

2. Native Heart Valve Function

   1. Front Matter

      Pages 1-1

      PDF

   2. Biological Mechanics of the Heart Valve Interstitial Cell

      • Alex Khang, Rachel M. Buchanan, Salma Ayoub, Bruno V. Rego, Chung-Hao Lee, Michael S. Sacks

      Pages 3-36

   3. Endothelial Mechanotransduction

      • James N. Warnock

      Pages 37-58

   4. The Role of Proteoglycans and Glycosaminoglycans in Heart Valve Biomechanics

      • Varun K. Krishnamurthy, K. Jane Grande-Allen

      Pages 59-79

   5. On the Unique Functional Elasticity and Collagen Fiber Kinematics of Heart Valve Leaflets

      • Jun Liao, Michael S. Sacks

      Pages 81-104

   6. Tricuspid Valve Biomechanics: A Brief Review

      • William D. Meador, Mrudang Mathur, Manuel K. Rausch

      Pages 105-114

   7. Measurement Technologies for Heart Valve Function

      • Morten O. Jensen, Andrew W. Siefert, Ikechukwu Okafor, Ajit P. Yoganathan

      Pages 115-149

3. Heart Valve Disease and Treatment

   1. Front Matter

      Pages 151-151

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   2. Calcific Aortic Valve Disease: Pathobiology, Basic Mechanisms, and Clinical Strategies

      • Payal Vyas, Joshua D. Hutcheson, Elena Aikawa

      Pages 153-179

   3. Remodelling Potential of the Mitral Heart Valve Leaflet

      • Bruno V. Rego, Sarah M. Wells, Chung-Hao Lee, Michael S. Sacks

      Pages 181-206

   4. Molecular and Cellular Developments in Heart Valve Development and Disease

      • Lindsey J. Anstine, Anthony S. Baker, Joy Lincoln

      Pages 207-239

   5. Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease

      • Ishita Tandon, Ngoc Thien Lam, Kartik Balachandran

      Pages 241-262

   6. Tissue Engineered Heart Valves

      • Jay M. Reimer, Robert T. Tranquillo

      Pages 263-288

   7. Decellularization in Heart Valve Tissue Engineering

      • Katherine M. Copeland, Bo Wang, Xiaodan Shi, Dan T. Simionescu, Yi Hong, Pietro Bajona et al.

      Pages 289-317

   8. Novel Bioreactors for Mechanistic Studies of Engineered Heart Valves

      • Kristin Comella, Sharan Ramaswamy

      Pages 319-335

   9. Bioprosthetic Heart Valves: From a Biomaterials Perspective

      • Naren Vyavahare, Hobey Tam

      Pages 337-382

4. Computational Approaches for Heart Valve Function

   1. Front Matter

      Pages 383-383

      PDF

   2. Computational Modeling of Heart Valves: Understanding and Predicting Disease

      • Ahmed A. Bakhaty, Ali Madani, Mohammad R. K. Mofrad

      Pages 385-411

   3. Biomechanics and Modeling of Tissue-Engineered Heart Valves

      • T. Ristori, A. J. van Kelle, F. P. T. Baaijens, S. Loerakker

      Pages 413-446

This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students. 

• GAGs in heart valve biomechanics
• automated heart valve bioreactors
• bending force in heart valve development
• biomechanics in mitral valve repairing
• biomechanics of myxoid mitral valves
• biomechanics of transcatheter heart valves
• biomechanics tissue engineered heart valves
• cardiac biomaterials
• computational modeling for the mitral heart valve
• computational modeling of heart valves
• decellularized heart valve scaffolds
• geometrical symmetry in bioprosthetic heart valve
• heart valve 3D printing
• heart valve calcification
• heart valve leaflets
• heart valve mechanotransduction
• heart valve tissue engineering
• mechanobiology of heart valve endothelial cells
• pregnancy-induced remodeling in heart valves
• viscoelasticity of heart valve tissues

• The Oden Institute and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, USA

  Michael S. Sacks

• The Department of Bioengineering, The University of Texas at Arlington, Arlington, USA

  Jun Liao

Dr. Michael Sacks is a Professor of Biomedical Engineering at The University of Texas at Austin. He is a world authority on cardiovascular biomechanics, particularly on the biomechanical behavior and function of heart valves and developing patient-specific simulation-based approaches for the treatment of valve diseases. His research is based on rigorous quantification, mathematical modeling, and simulation of the mechanical behavior of the cells and tissues of the cardiovascular system in health and disease. His approaches include multi-scale studies of cell/tissue/organ, especially how they mechanical interact as a system. Dr. Sacks is also active in the biomechanics of engineered tissues and scaffolds and in understanding the in-vitro and in-vivo remodeling processes from a functional biomechanical perspective.


Dr. Jun Liao is an Associate Professor of Biomedical Engineering at the University of Texas at Arlington. Dr. Liao is an expert in tissue biomechanics and bioengineering, with interests in heart valves, cardiac muscle, and many other soft tissues. His research focus is to better understand the role of biomechanics in maintaining optimal tissue performance in physiological conditions and the biomechanical abnormality in diseased conditions, aiming to improving tissue replacement, repair, and medical intervention for diseases. Dr. Liao is a member of BMES, ASME, and AAAS and a Fellow of the American Heart Association. 

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