Advanced High-Resolution Tomography in Regenerative Medicine

1. Front Matter

   Pages i-xiv

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2. The Huge Machines of Physics: The Bet of the Multidisciplinary Research Teams in Regenerative Medicine

   • Franco Rustichelli

   Pages 1-17

3. Introduction to X-Ray Micro-tomography

   • Serena Pacilè, Giuliana Tromba

   Pages 19-39

4. Role of Benchtop Microtomographic Systems in Tissue Engineering

   • Rossella Bedini, Deborah Meleo, Raffaella Pecci

   Pages 41-50

5. Synchrotron Radiation X-Ray Phase-Contrast Microtomography: What Opportunities More for Regenerative Medicine?

   • Ginevra Begani Provinciali, Nicola Pieroni, Inna Bukreeva

   Pages 51-68

6. From Projections to the 3D Analysis of the Regenerated Tissue

   • Francesco Brun

   Pages 69-90

7. In-Line X-Ray Phase Tomography of Bone and Biomaterials for Regenerative Medicine

   • Max Langer

   Pages 91-109

8. Inside the Bone: Tissue Engineering and Regenerative Medicine Applications in Orthopedics

   • Marta Nardini, Maria Elisabetta Federica Palamà, Alessio Romaldini, Milena Mastrogiacomo

   Pages 111-122

9. Bone Regeneration: Experiences in Dentistry

   • Serena Mazzoni

   Pages 123-137

10. The Challenge of the Vascularization of Regenerated Tissues

    • Michela Fratini

    Pages 139-149

11. Synchrotron X-Ray-Based Functional and Anatomical Lung Imaging Techniques

    • Sam Bayat, Christian Dullin, Marcus J. Kitchen, Goran Lovric

    Pages 151-167

12. Better Cartilage Imaging at Synchrotron Facilities

    • Annie Horng

    Pages 169-179

13. Into the Heart: What Contributions to Cardiac Regeneration?

    • Alessandra Giuliani, Mara Mencarelli

    Pages 181-194

14. Frontiers in Muscle Diseases: The X-ray Microtomography Support to Latest Researches

    • Fabrizio Fiori

    Pages 195-203

15. Nervous Tissue and Neuronal Cells: Patterning by Electrophoresis for Highly Resolved 3D Images in Tissue Engineering

    • Rolf Zehbe, Kerstin Zehbe

    Pages 205-215

16. X-Ray Phase Contrast Tomography in Tissue Engineering: Focus on Laboratory Implementations

    • Charlotte K. Hagen

    Pages 217-232

This book covers the state-of-the-art research on advanced high-resolution tomography, exploring its role in regenerative medicine. and also explores the 3D interactions between tissues, cells, and biomaterials. Various multidisciplinary paths in regenerative medicine are covered, including X-ray microtomography and its role in regenerative medicine, synchrotron radiation-based microtomography and phase contrast tomography, the challenge of the vascularization of regenerated tissues, lung and cartilage imaging, and more. This is an ideal book for biomedical engineers, biologists, physicists, clinicians, and students who want to pursue their studies in the field of regenerative medicine.

This book also:

Reviews in detail the algorithms and software used for the 3D exploration of regenerated tissue

Covers the latest research on the use of X-ray microtomography for muscle diseases

Details applications of synchrotron radiation tomography in orthopedicsand dentistry

• X-ray Microtomography
• X-ray Microtomography Regenerative
• Synchrotron Radiation Microtomography
• 3D Exploration Regenerative Tissue
• Vascularization Regenerated Tissues
• Lung Imaging Pulmonary Diseases
• Imaging Synchrotron Facilities
• Cardiac Regeneration microtomography
• Muscle X-ray microtomography
• In-line Phase Tomography

• Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy

  Alessandra Giuliani

• Institute of Nanotechnology - CNR, c/o Sapienza University, Rome, Italy

  Alessia Cedola

Alessandra Giuliani is a Senior Scientist in Applied Physics at the Faculty of Medicine of the Polytechnic University of Marche (Ancona, Italy). Her research activity is focused on issues related to tissue engineering and particularly on the characterization of constructs for the study/regeneration of bone and muscle tissue through advanced physical techniques, including high-resolution X-ray tomography.

Alessia Cedola, Italian citizen, received in 1999 the PhD degree summa cum laude at the University “Joseph Fourier" in Grenoble (France) with an experimental thesis at European Synchrotron Radiation Facility (ESRF). She is currently permanent senior scientist of the National Research Council (CNR) at Institute of Nanotechnology in Rome.  She is enabled Associate Professor of Experimental Physics. She is responsible of the X-ray physics group at CNR in Rome.  

Member of,

i)  Two Management Committees of the European Science Foundation Project COST,

ii)  Scientific Committee of several International conferences on physics and X-ray optics.,

iii) Editorial Board of the Journal Scientific Reports – Nature.

She is currently principal investigator of several European and National financed projects. She works on X-ray imaging, X-ray Phase Contrast Tomography applied to Biomedical applications. She received several invitation to plenary and talks. She has more than 120 publications with 1400 citations.

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