Progress in Human African Trypanosomiasis, Sleeping Sickness

1. Front Matter

   Pages I-XIII

   PDF

2. ‘Trypanosomiasis exists when it is searched for…’

   • J. L. Frézil

   Pages 1-5

3. Identification of trypanosomes: from morphology to molecular biology

   • W. Gibson, J. Stevens, P. Truc

   Pages 7-29

4. Antigenic variation in African trypanosomes

   • E. Pays

   Pages 31-52

5. Carbohydrate metabolism

   • F. R. Opperdoes

   Pages 53-80

6. Polyamine metabolism

   • J. C. Breton, B. Bouteille

   Pages 81-104

7. Cytokines and the blood-brain barrier in human and experimental African trypanosomiasis

   • V. W. Pentreath

   Pages 105-117

8. Cytokines in the pathogenesis of human African trypanosomiasis: antagonistic roles of TNF-α and IL-10

   • S. G. Rhind, P. N. Shek

   Pages 119-135

9. Immunology of African trypanosomiasis

   • P. Vincendeau, M. O. Jauberteau-Marchan, S. Daulouède, Z. Ayed

   Pages 137-156

10. Pathology of African trypanosomiasis

    • K. Kristensson, M. Bentivoglio

    Pages 157-181

11. Hormones in human African trypanosomiasis

    • M. W. Radomski, G. Brandenberger

    Pages 183-190

12. Sleeping sickness: a disease of the clock with nitric oxide involvement

    • A. Buguet, R. Cespuglio

    Pages 191-201

13. Electroencephalographic features and evoked potentials in human African trypanosomiasis

    • F. Tabaraud, P. Tapie

    Pages 203-213

14. Clinical aspects of human African trypanosomiasis

    • M. Dumas, S. Bisser

    Pages 215-233

15. Biological diagnosis of human African trypanosomiasis

    • N. Van Meirvenne

    Pages 235-252

16. Present strategies in the treatment of human African trypanosomiasis

    • S. Van Nieuwenhove

    Pages 253-280

17. The nitroimidazoles and human African trypanosomiasis

    • G. Chauvière, J. Périé

    Pages 281-287

18. Experimental models for new chemotherapeutic approaches to human African trypanosomiasis

    • B. Bouteille, M. Keita, B. Enanga, J. Mezui Me Ndong

    Pages 289-300

19. Prophylactic strategies in human African trypanosomiasis

    • A. Stanghellini

    Pages 301-313

20. International co-operation: past and present

    • P. de Raadt, J. Jannin

    Pages 315-333

Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

• biology
• fields
• metabolism
• pathogenesis
• therapy
• infectious diseases

• Faculté de Médecine Institut d’Épidemiologie Neurologique et de Neurologie Tropicale, Université de Limoges, Limoges, France

  Michel Dumas, Bernard Bouteille

• Unité de Physiologie de la Vigilance, Centre de Recherches du Service de Santé des Armées Émile Pardé, La Tronche Cedex, France

  Alain Buguet

Policies and ethics