Homocysteine

1. Front Matter

   Pages 1-10

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2. Introduction

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 11-13

3. What is Homocysteine?

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 15-19

4. Homocysteine Metabolism

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 21-33

5. How can Homocysteine be Neurotoxic?

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 35-57

6. Why do Homocysteine Levels increase?

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 59-108

7. Neuropsychiatric Conditions associated with Hyperhomocysteinemia

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 109-149

8. Clinical Impact of Enzyme Defects

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 151-161

9. When and how to check Homocysteine Levels?

   • Christina Bolander-Gouaille, Teodoro Bottiglieri

   Pages 163-169

10. How to interpret the Test Results and how to handle Hyperhomocysteinemia?

    • Christina Bolander-Gouaille, Teodoro Bottiglieri

    Pages 171-182

11. Back Matter

    Pages 183-219

    PDF

During the last 15 years the research on homocysteine and the vitamins involved in its metabolism has become very dynamic. About 1,500 publications on the subject are now published each year. The research has long mainly focused on the association between homocysteine and cardiovascular disease, but also pregnancy complications/ fetal malformations. There is, however, an increasing interest in the connection between the homocysteine metabolism and neuropsychiatric disease with a steeply increasing number of publications. In particular, the association between homocysteine metabolism and cognitive decline/dementia attracts much interest. If simple, non-toxic homocysteine-lowering treatment with vitamins can reduce the incidence of, or delay the onset of dementia, it would have an enormous impact in societies with a rapidly increasing number of elderly at risk for dementia. This book summarises the research within the neuropsychiatric field, but also gives an overview of the underlying biochemistry and of diagnostic aspects. About 1,000 references are given. Christina Bolander-Gouaille, a pharmacist, has for over 10 years specialised in writing reviews/monographs on homocysteine and related vitamins. This is her third book in a series edited by Springer Verlag. This book, however, is written in collaboration with Teodoro Bottiglieri, who is director of neuropharmacology and senior research scientist at Baylor University, Institute for Metabolic Diseases in Dallas, USA.

• Depression
• Vitamin B12
• Vitamin B6
• cobalamin
• dementia
• drug interactions
• enzyme defecte
• folate
• folic acid
• homocysteine
• lifestyle factors
• methylenetetrahydrofolate reductase
• neuropsychiatry
• pyridoxine
• riboflavine

• Helsingborg, Sweden

  Christina Bolander-Gouaille

• Institute of Metabolic Disease, Baylor University Medical Center, 3812 Elm Street, Texas

  Teodoro Bottiglieri

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