Pancreatic Disease

1. Front Matter

   Pages i-xi

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2. Potential Trials in Acute Pancreatitis

   1. Front Matter

      Pages 1-1

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   2. Acute Pancreatitis in Intensive Care

      • John Kinsella, Barry Clements, Euan Dickson, Thierry Dugernier, Martin Hughes

      Pages 3-9

   3. Antibiotic Prophylaxis in Acute Severe Pancreatitis: Should We Have a Further Study?

      • Jens Werner, Kevin C. P. Conlon, Hjalmar C. van Santvoort, Caroline S. Verbeke, Sakhawat H. Rahman

      Pages 11-19

   4. Designing an Optimal Study for the Management of Infected Pancreatic Necrosis

      • Marc G. H. Besselink, Hjalmar C. van Santvoort, Ross Carter, Richard M. Charnley, Damian J. Mole, Hein G. Gooszen

      Pages 21-30

   5. Nutrition in Acute Pancreatitis

      • Hemant M. Kocher, Christos Dervenis, Attila Oláh, William R. Murray, Barry Clements, Clement W. Imrie

      Pages 31-40

   6. An Optimal Randomized Study for Pain Control in Acute Pancreatitis

      • Åke Andrén-Sandberg, Julia V. Mayerle, Ajith K. Siriwardena, David P. Berry, Gareth R. Kirk, Markus M. Lerch

      Pages 41-49

3. Potential Trials in Chronic Pancreatitis

   1. Front Matter

      Pages 52-52

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   2. Endoscopic Versus Surgical Drainage for Chronic Pancreatitis

      • Stephen P. Pereira, Shivi S. Siva, Colin D. Johnson

      Pages 53-66

   3. Duodenum-Preserving Pancreatic Resection with Pancreatic Duct Drainage: What Is the Role of Supraduodenal Biliary Drainage?

      • Emre F. Yekebas, Christos Dervenis, Richard M. Charnley, Bettina M. Rau, Jens Werner, Clement W. Imrie

      Pages 67-70

4. Potential Trials in Pancreatic Cancer

   1. Front Matter

      Pages 72-72

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   2. Pain Management and Nutritional Support in Nonresectable Pancreatic Cancer

      • David P. Berry, Richard M. Charnley, Christos Dervenis, Gareth R. Kirk, Francis Regan, Emre F. Yekebas et al.

      Pages 73-77

   3. Endoscopic Therapy in the Palliation of Nonresectable Pancreatic Cancer

      • Attila Oláh, William R. Murray, Colin J. McKay, Åke Andrén-Sandberg, Sakhawat H. Rahman, Colin D. Johnson

      Pages 79-83

   4. Pancreatic Endocrine Tumors

      • Damian J. Mole, Caroline S. Verbeke, Nicholas S. Reed

      Pages 85-96

   5. The Role of the Systemic Inflammatory Response in Predicting Outcome in Patients with Pancreatic Cancer

      • Donald C. McMillan

      Pages 97-102

5. Topic Reviews

   1. Front Matter

      Pages 104-104

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   2. Botulinum Toxin and the Sphincter of Oddi

      • William R. Murray

      Pages 105-108

   3. The European Study Group for Pancreatic Cancer (ESPAC) Trials

      • Paula Ghaneh, Khaled Dajani, Michael G. T. Raraty, Robert Suttton, John P. Neoptolemos

      Pages 109-121

6. Back Matter

   Pages 123-125

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Clem Imrie and Colin Johnson This book stems from an unusual meeting held in The Royal College of Physicians and Surgeons of Glasgow in March 2007. Enthusiastic doctors in the diagnosis and treatment of pancreatic diseases were arranged in small groups to discuss specific unsolved/partially clinical problems and suggest the way forward. In some instances, the recommendations were initial improved longitudinal studies, while in others better double-blind randomized st- ies. The recommendations were then presented on the second day before the total 40 plus participants who added their input. Finally, the mechanics of initiating the proposals were arranged. The editors are most thankful to the authors from the meeting, who have ass- bled the various contributions to this stimulating volume. xi Part I Potential Trials in Acute Pancreatitis Chapter 1 Acute Pancreatitis in Intensive Care John Kinsella, Barry Clements, Euan Dickson, Thierry Dugernier, and Martin Hughes 1.1 Intr oduction Severe acute pancreatitis is associated with the development of the systemic inflammatory response syndrome (SIRS). Hypoxemia is a hallmark of acute pancreatitis and respiratory failure is the most common single organ failure in this disease. In the most severely ill patients mul- organ dysfunction syndrome (MODS) and multi-organ failure (MOF) occur. Intensive care with multiple organ support is necessary.

• Gastroenterology
• Hematology
• Oncology
• Pancreatic Disease
• endoscopy

From the reviews: “This book focuses on evidence-based practice in the treatment of patients with pancreatic disease. It includes studies evaluating treatment efficacy in both benign (acute and chronic pancreatitis) and malignant (pancreatic cancer) diseases. … It is intended for gastroenterologists, gastrointestinal surgeons, or surgical oncologists who see patients with pancreatic disease. … This is an excellent book for organizing current studies in pancreatic disease. Specific surgical or endoscopic techniques are … nicely referenced.” (Joseph J. Cullen, Doody’s Review Service, May, 2010)

• Univ. Surgical Unit, Southampton General Hospital, Southampton, United Kingdom

  Colin D. Johnson

• Royal Infirmary, Dept. Surgery, University Glasgow, Glasgow, United Kingdom

  Clement W. Imrie

Colin Johnson

Reader in Surgery, University of Southampton, Southampton, Hampshire, UK

Clem Imrie

Professor of Surgery, Glasgow Royal Infirmary, Glasgow, UK

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