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Management of Breast Cancer in Older Women

  • Book
  • © 2010

Overview

Editors:
  1. Malcolm W. Reed

    1. Sheffield, United Kingdom

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  2. Riccardo A. Audisio

    1. St Helens, United Kingdom

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  • The proposed contributors to this text represent the leading opinions in their relevant fields. This will ensure the credibility of this text with the proposed readership.
  • The text covers all aspects of the care of older women with breast cancer rather than being sub-specialist specific. This will attract a wide range of potential readers for the text.
  • Dr Audisio is a board member of SIOG and the endorsement of this association will be sought. This will provide marketing opportunities through the Society website and meetings.

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Background and Epidemiology

    1. Front Matter

      Pages 1-1
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    2. Basic Science of Breast Cancer in Older Patients

      • Irmgard Irminger-Finger
      Pages 3-19

    3. Tumor Biology and Pathology

      • Virginie Durbecq, Denis Larsimont
      Pages 21-35

    4. Clinical Epidemiology and the Impact of Co-Morbidity on Survival

      • Adri C. Voogd, Marieke J. Louwman, Jan Willem W. Coebergh
      Pages 37-50

  3. Special Considerations in the Management of Older Women

    1. Front Matter

      Pages 52-52
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    2. Comprehensive Geriatric Assessment

      • Margot A. Gosney
      Pages 53-63

    3. A Practical Mini-Guide to Comprehensive Geriatric Assessment

      • Siri Rostoft Kristjansson
      Pages 65-74

    4. Impact of the Physiological Effects of Aging on the Pharmacokinetics and Pharmacodynamics of Systemic Breast Cancer Treatment

      • Paul Hamberg, Maja J. A. de Jonge, Caroline M. Seynaeve
      Pages 75-99

    5. Impact of Hormone Replacement Therapy on Breast Cancer

      • Toral Gathani, Valerie Beral
      Pages 101-108

    6. Experiences of a Multidisciplinary Elderly Breast Cancer Clinic: Using the Right Specialists, in the Same Place, with Time

      • Anne Stotter, Mohammad Tahir, Robert S. Pretorius, Thompson Robinson
      Pages 109-123

  4. Therapeutics

    1. Front Matter

      Pages 126-126
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    2. Mammographic Breast Screening in Elderly Women

      • Lynda Wyld
      Pages 127-142

    3. Primary Endocrine Therapy for the Treatment of Early Breast Cancer in Older Women

      • Lynda Wyld, Daniel Hind
      Pages 143-164

    4. Peroperative Radiotherapy

      • Roberto Orecchia, Giovanni Battista Ivaldi, Maria Cristina Leonardi
      Pages 165-181

    5. General and Local Anesthetics

      • Bernadette Th. Veering
      Pages 183-195

    6. The Surgical Management of Breast Cancer in Elderly Women

      • Malcolm W. R. Reed, Lynda Wyld, Riccardo A. Audisio
      Pages 197-211

    7. Breast Reconstruction

      • Marcus J. D. Wagstaff, Malcolm W. R. Reed, Christopher M. Caddy
      Pages 213-229

    8. Adjuvant Endocrine Therapy

      • Laura Biganzoli
      Pages 231-247

    9. Adjuvant Chemotherapy

      • Sumanta Kumar Pal, Nilesh Vora, Arti Hurria
      Pages 249-262
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Keywords

About this book

I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result, she was taking a grand total of 500 mg of capecitabine a day. Yet, her metastatic, ER/PR-negative, Her2-positive breast cancer was undoubtedly responding. Her pain was improving and her chest mass was shrinking, as were her lung metastases… What was the secret of that response? Were Mrs T’s kidneys eli- nating even less drug than predicted by her creatinine clearance? Was her sarcopenia altering drug distribution? Was she absorbing more drug than average? Or was her tumor exquisitely sensitive to fluoropyrimidines? “Physicians,” said Voltaire, “pour drugs they know little for diseases they know even less into patients they know no- ing about.” Medicine has made tremendous progress since the eighteenth century. Yet, there are fields where quite a lot remains to be learned. In developed countries, 25% of breast cancers occur in patients aged 75 years and older. Yet, these patients represent only 4% of the population of traditional clinical trials. That ought to let us wonder how relevant data acquired in patients in their 60s are to a nonagenarian. Fortunately, geriatric oncologists have been stepping up to the task and have gen- ated data to help us to treat such patients.

Reviews

From the reviews:

“This book is to provide readers with a review of the management of breast cancer in the older woman. … volume provides a detailed background to each topic with clear and helpful evidence based guidance. … book succeeds in providing evidence based guidance on virtually all aspects of breast cancer management. It represents good value for money … and is an asset to the library. It is suitable for the established clinician, trainee oncologist and to other members of the breast multidisciplinary team.” (Karin Baria, Oncology News, Vol. 8 (2), May/June, 2013)

“A slim but comprehensive review of the issues related to treating breast cancer in older patients. … it includes information about geriatrics as well as breast cancer biology and brings it all together in the treatment chapters. … Intended for practitioners who are taking care of older women with breast cancer, this book is aimed at not only cancer specialists, but also primary care physicians. … an excellent book that will provide guidance to a wide range of specialists who take care of these women.” (Carol Scott-Conner, Doody’s Book Reviews, August, 2011)

“Reed and Riccardo, have an established research and clinical interest in management of older women with breast cancer and have assembled a multidisciplinary panel of experts who contributed to various chapters in their field of expertise. … The book aims to provide readers with the best available evidence in this field. … a very well-written book and the editors and contributors have done justice to this topic. … a valuable resource for clinicians and other health-care professionals who deal with elderly patients with breast cancer.” (Mohammed Keshtgar, British Journal of Hospital Medicine, Vol. 72 (4), April, 2011)

Editors and Affiliations

  • Sheffield, United Kingdom

    Malcolm W. Reed

  • St Helens, United Kingdom

    Riccardo A. Audisio

Bibliographic Information

  • Book Title: Management of Breast Cancer in Older Women

  • Editors: Malcolm W. Reed, Riccardo A. Audisio

  • DOI: https://doi.org/10.1007/978-1-84800-265-4

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London Limited 2010

  • Hardcover ISBN: 978-1-84800-264-7Published: 12 January 2010

  • eBook ISBN: 978-1-84800-265-4Published: 18 January 2010

  • Edition Number: 1

  • Number of Pages: XVI, 413

  • Topics: Oncology, Geriatrics/Gerontology, Diagnostic Radiology, Surgical Oncology

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