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Osteoporosis in Older Persons

Pathophysiology and Therapeutic Approach

  • Book
  • © 2009

Overview

Editors:
  1. Gustavo Duque

    1. Division of Geriatric Medicine-Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Douglas P. Kiel

    1. Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Describes the epidemiology of osteoporotic fractures and their impact on health care costs

  • Integrates the subject of falls with the one on fractures - widely neglected by most of the textbooks on osteoporosis

  • A complete review on the prevention as well as current and future treatments of osteoporosis

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Biology of Bone

    • Paul C. Schiller, Gianluca D'Ippolito, Guy A. Howard
    Pages 1-18

  3. Aging and Bone

    • Jeffrey M. Gimble, Z. Elizabeth Floyd, Moustapha Kassem, Mark E. Nuttall
    Pages 19-33

  4. Calciotropic Hormones

    • E. Paul Cherniack, Bruce R. Troen
    Pages 34-46

  5. Sex Steroids and Aging Bone

    • Jane A. Cauley
    Pages 47-58

  6. Animal Models for Senile Osteoporosis

    • Ken Watanabe
    Pages 59-70

  7. Senile Osteoporosis as a Geriatric Syndrome

    • Rujuta H. Patel, Kenneth W. Lyles
    Pages 71-81

  8. Genetics of Osteoporosis in Older Age

    • David Karasik, Douglas P. Kiel
    Pages 82-96

  9. Fracture Epidemiology Among Individuals 75+

    • Heike A. Bischoff-Ferrari
    Pages 97-109

  10. Falls as a Geriatric Syndrome: How to Prevent Them? How to Treat Them?

    • Manuel Montero-Odasso
    Pages 110-125

  11. Non-Pharmacological Treatments for Falls and Fractures

    • Stephen R. Lord, Jacqueline C. T. Close, Catherine Sherrington
    Pages 126-136

  12. Medical Treatment of Age-Related Osteoporosis: Present and Future

    • Steven Boonen
    Pages 137-152

  13. Treatment of Osteoporosis in Long-Term Care

    • Gustavo Duque, Louise Mallet
    Pages 153-162

  14. Fracture Care in the Elderly

    • Christopher M. Bono, Timothy Bhattacharyya
    Pages 163-180

  15. Back Matter

    Pages 181-186
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Keywords

About this book

Although osteoporosis has been de? ned as “a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk,” it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized “osteoporosis of old age” and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that “in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. ” In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system.

Reviews

From the reviews:

"The authors of this multiauthored book bring together new information on the molecular biology of bone physiology in this examination of osteoporosis in older persons. … The intended audience includes all health practitioners who treat older patients with osteoporosis. Research scientists in the area will find this book useful as well. … This book’s demonstration of the complex relationship of bone health to adipose tissue and several powerful hormones will stimulate new thinking in the area of osteoporosis." (David O. Staats, Doody’s Review Service, August, 2008)

"This is a simply outstanding compilation that provides a clear and concise review of the effect age has on the skeleton at the molecular/genetic level, in animal models as well as humans. … It provides clinicians with an overview of cellular mechanisms leading to bone loss and researchers with insight into the clinical consequences of age-related skeletal change in older adults. That such a text has not previously been written and become a reference standard among clinicians, geriatricians, and researchers … ." (Neil Binkley, JAMA, Vol. 300 (11), September, 2008)

Editors and Affiliations

  • Division of Geriatric Medicine-Jewish General Hospital, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada

    Gustavo Duque

  • Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, USA

    Douglas P. Kiel

Bibliographic Information

  • Book Title: Osteoporosis in Older Persons

  • Book Subtitle: Pathophysiology and Therapeutic Approach

  • Editors: Gustavo Duque, Douglas P. Kiel

  • DOI: https://doi.org/10.1007/978-1-84628-697-1

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London 2009

  • Hardcover ISBN: 978-1-84628-515-8Published: 23 January 2008

  • Softcover ISBN: 978-1-84882-924-4Published: 16 November 2009

  • eBook ISBN: 978-1-84628-697-1Published: 13 October 2009

  • Edition Number: 1

  • Number of Pages: XVIII, 186

  • Number of Illustrations: 125 illustrations in colour

  • Topics: Rheumatology, Orthopedics, Endocrinology, Geriatrics/Gerontology

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