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Bone Resorption

  • Book
  • © 2005

Overview

Editors:
  1. Felix Bronner

    1. Department of BioStructure and Function, University of Connecticut Health Center, Farmington, USA
      Department of Pharmacology, University of Connecticut Health Center, Farmington, USA

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  2. Mary C Farach-Carson

    1. Department of Biology, University of Delaware, Newark, USA

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  3. Janet Rubin

    1. Division of Endocrinology and Metabolism, Emory University School of Medicine, Veterans Affairs Medical Center, Decatur, USA

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  • There is currently no single book with up to date information on osteoclast function and bone resorption
  • A useful collection of information, not readily available in a concentrated and convenient form on the market
  • Provides a comprehensive overview of the field

Part of the book series: Topics in Bone Biology (TBB, volume 2)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Osteoclast: Origin and Differentiation

    • Janet Rubin, Edward M. Greenfield
    Pages 1-23

  3. Osteolytic Enzymes of Osteoclasts

    • Merry Jo Oursler
    Pages 24-33

  4. Regulation of Osteoclast Activity

    • Roland Baron, William C. Horne
    Pages 34-57

  5. Structural Aspects of Bone Resorption

    • Steven D. Bain, Ted S. Gross
    Pages 58-66

  6. Inflammatory Cytokines

    • Mark S. Nanes, Roberto Pacifici
    Pages 67-90

  7. Genetics and Mutations Affecting Osteoclast Development and Function

    • Mark C. Horowitz, Melissa A. Kacena, Joseph A. Lorenzo
    Pages 91-107

  8. Clinical Disorders Associated with Alterations in Bone Resorption

    • Janet Rubin, Mark S. Nanes
    Pages 108-127

  9. Pharmaceuticals for Bone Disease Targeting the Osteoclast

    • Lorraine A. Fitzpatrick
    Pages 128-150

  10. Skeletal Complications of Malignancy: Central Role for the Osteoclast

    • Gregory A. Clines, John M. Chirgwin, Theresa A. Guise
    Pages 151-174

  11. Back Matter

    Pages 175-189
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Keywords

About this book

Bone Resorption, the second volume in the series Topics in Bone Biology, deals with the osteoclast, the bone-resorbing cell, its origins, its enzymes, the regulation of osteoclast activity, and structural aspects of bone resorption. Diseases involving osteoclast function are discussed from the genetic viewpoint in two chapters that span transgenic mouse models to human pathology. Another chapter treats diseases of osteoclast function. Because osteoporosis may be considered a disease in which the bone resorption rate exceeds formation, a separate chapter deals with current and potential therapeutic approaches to this widespread disease that affects both men and women. Bone metastases and an analysis of the central role of the osteoclast in this condition are treated in the concluding chapter.

The reviews in the book are essential reading for clinicians, researchers and students in a variety of fields: skeletal biology and orthopedics, nutrition, rheumatology, endocrinology, nephrology, oncology, dentistry, nursing, and chiropractic medicine. Together with the earlier volume on Bone Formation, this volumes serves as a beacon to a field that has become a major topic for those who study the health concerns of the aged, the very young, athletes and those with cancer.

Reviews

From the reviews:

"Volume 2 in the series Bone Biology and written by US experts, it reviews in 9 chapters the biology, physiology and physiopathology of the osteoclast. It also describes the new drugs which inhibit bone resorption. A very complete, well referenced text, of interest to all who research or treat bone diseases, including pediatric endocrinologists." (Zvi Laron, Pediatric Endocrinology Reviews, Vol. 3 (2), 2005)

Editors and Affiliations

  • Department of BioStructure and Function, University of Connecticut Health Center, Farmington, USA

    Felix Bronner

  • Department of Pharmacology, University of Connecticut Health Center, Farmington, USA

    Felix Bronner

  • Department of Biology, University of Delaware, Newark, USA

    Mary C Farach-Carson

  • Division of Endocrinology and Metabolism, Emory University School of Medicine, Veterans Affairs Medical Center, Decatur, USA

    Janet Rubin

Bibliographic Information

  • Book Title: Bone Resorption

  • Editors: Felix Bronner, Mary C Farach-Carson, Janet Rubin

  • Series Title: Topics in Bone Biology

  • DOI: https://doi.org/10.1007/b136184

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London 2005

  • Hardcover ISBN: 978-1-85233-812-1Published: 08 August 2005

  • Softcover ISBN: 978-1-84996-926-0Published: 22 October 2010

  • eBook ISBN: 978-1-84628-016-0Published: 17 January 2006

  • Series ISSN: 2199-2436

  • Series E-ISSN: 2199-2444

  • Edition Number: 1

  • Number of Pages: XIV, 190

  • Topics: Rheumatology, Orthopedics, Internal Medicine, Endocrinology

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