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G Protein-Coupled Receptor Genetics

Research and Methods in the Post-Genomic Era

  • Book
  • © 2014

Overview

Editors:
  1. Craig W. Stevens

    1. Oklahoma State University, Tulsa, USA

    View editor publications

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  • Explores the powerful and versatile g protein-coupled receptors and their application in health and medicine
  • Features practical methods that are lab-proven and ready to use
  • Includes expert opinions on the future directions of the rapidly progressing field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (21 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Genetic Mechanisms of G Protein-Coupled Receptors

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. G Protein-Coupled Receptors: Research and Methods in the Post-Genomic Era

      • Craig W. Stevens
      Pages 3-22

    3. Examining the Dynamic Evolution of G Protein-Coupled Receptors

      • Claudia Stäubert, Diana Le Duc, Torsten Schöneberg
      Pages 23-43

    4. Functional Properties of Virus-Encoded and Virus-Regulated G Protein-Coupled Receptors

      • Katja Spiess, Mette M. Rosenkilde
      Pages 45-65

    5. Discovery and Function of the Very Large G Protein-Coupled Receptor

      • Perrin C. White, D. Randy McMillan
      Pages 67-83

    6. Functional Evolution of Opioid Family G Protein-Coupled Receptors

      • Eyal Vardy, Craig W. Stevens, Bryan L. Roth
      Pages 85-104

    7. Investigation of G Protein-Coupled Receptor Function and Regulation Using Antisense

      • Jonathon Willets, Craig Nash
      Pages 105-126

    8. Signalosome Profiling Reveals Allosteric Interactions Between G Protein-Coupled Receptors

      • Katrin Altosaar, Darlaine Pétrin, Dominic Devost, Terence E. Hébert
      Pages 127-146

  3. Genetic Toolbox for G Protein-Coupled Receptor Discovery

    1. Front Matter

      Pages 147-147
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    2. Use of Optogenetic Approaches to Control Intracellular Signaling of G Protein-Coupled Receptors

      • Olivia A. Masseck, Melanie D. Mark, Stefan Herlitze
      Pages 149-160

    3. Viral Infection for G Protein-Coupled Receptor Expression in Eukaryotic Cells

      • Antonio Porcellini, Luisa Iacovelli, Antonio De Blasi
      Pages 161-175

    4. Using In Vitro Mutagenesis to Characterize Structure-Function Relationships in G Protein-Coupled Receptors

      • Gregory W. Sawyer, Frederick J. Ehlert
      Pages 177-195

    5. The CRE Luc Mouse Model for Bioimaging Ligand Activation of G Protein-Coupled Receptors

      • H. Gregory Polites, Kyriakos D. Economides
      Pages 197-217

    6. Inducing Conformational Changes in G Protein-Coupled Receptors by Domain Coupling

      • Hamiyet Unal, Sadashiva S. Karnik
      Pages 219-237

    7. Rescue of Defective G Protein-Coupled Receptor Function by Intermolecular Cooperation

      • Ashutosh Trehan, Kim Carol Jonas, Ilpo Huhtaniemi, Aylin Carla Hanyaloglu, Adolfo Rivero-Müller
      Pages 239-255

    8. Design of Super-arrestins for Gene Therapy of Diseases Associated with Excessive Signaling of G Protein-Coupled Receptors

      • Vsevolod V. Gurevich, Eugenia V. Gurevich
      Pages 257-285

  4. Genetic Aspects of G Protein-Coupled Receptors in Health and Medicine

    1. Front Matter

      Pages 287-287
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    2. Importance of G Protein-Coupled Receptor Genetics in Clinical Medicine

      • Ramakrishna Devaki
      Pages 289-298

    3. Pharmacogenomics of G Protein-Coupled Receptor Signaling and Other Pathways in Essential Hypertension

      • Pedro A. Jose, Van Anthony M. Villar, Matthew R. Weir, Robin A. Felder
      Pages 299-312
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Keywords

About this book

G Protein‐Coupled Receptor Genetics: Research and Methods in the Post‐Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab.

Authoritative and easy to use, G Protein‐Coupled Receptor Genetics: Research and Methods in the Post‐Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.

Editors and Affiliations

  • Oklahoma State University, Tulsa, USA

    Craig W. Stevens

Bibliographic Information

  • Book Title: G Protein-Coupled Receptor Genetics

  • Book Subtitle: Research and Methods in the Post-Genomic Era

  • Editors: Craig W. Stevens

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-62703-779-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-62703-778-5Published: 24 January 2014

  • Softcover ISBN: 978-1-4939-6332-4Published: 17 September 2016

  • eBook ISBN: 978-1-62703-779-2Published: 24 January 2014

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XI, 423

  • Number of Illustrations: 26 b/w illustrations, 40 illustrations in colour

  • Topics: Pharmacology/Toxicology, Proteomics

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