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Ocular Pharmacology and Toxicology

  • Book
  • © 2014

Overview

Editors:
  1. Brian C. Gilger

    1. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, USA

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  • Serves as an ideal training manual for exploring design and conduct of ocular pharmacology and toxicology studies
  • Features practical methodologies that are tested and successful
  • Includes study design, analysis, and routes to regulatory approval for a variety of ophthalmic drugs

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (12 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Challenges in Ocular Pharmacokinetics, Pharmacodynamics, and Toxicology

    • Brian C. Gilger
    Pages 1-6

  3. Selection of Appropriate Animal Models in Ocular Research: Ocular Anatomy and Physiology of Common Animal Models

    • Brian C. Gilger, Eva Abarca, Jacklyn H. Salmon
    Pages 7-32

  4. Challenges and Strategies in Drug Residue Measurement (Bioanalysis) of Ocular Tissues

    • Poonam R. Velagaleti, Michael H. Buonarati
    Pages 33-52

  5. Chemistry, Manufacturing, and Control of Ophthalmic Formulations

    • Malay Ghosh, Imran Ahmed
    Pages 53-79

  6. ADME and Ocular Therapeutics: Retina

    • Cornelis J. Van der Schyf, Samuel D. Crish, Christine Crish, Denise Inman, Werner J. Geldenhuys
    Pages 81-89

  7. Compositions, Formulation, Pharmacology, Pharmacokinetics, and Toxicity of Topical, Periocular, and Intravitreal Ophthalmic Drugs

    • Kishore Cholkar, Aswani Dutt Vadlapudi, Hoang M. Trinh, Ashim K. Mitra
    Pages 91-118

  8. Sustained-Release Ocular Drug Delivery Systems: Bench to Bedside Development

    • Susan S. Lee, Michael R. Robinson, Scott M. Whitcup
    Pages 119-142

  9. The Ophthalmic Examination as It Pertains to General Ocular Toxicology: Basic and Advanced Techniques and Species-Associated Findings

    • David A. Wilkie
    Pages 143-203

  10. Study Design and Methodologies for Evaluation of Anti-glaucoma Drugs

    • Paul E. Miller
    Pages 205-242

  11. Study Design and Methodologies for Study of Ocular Medical Devices

    • Joseph W. Carraway, Elaine M. Daniel
    Pages 243-265

  12. Methodologies for Microscopic Characterization of Ocular Toxicity

    • Leandro B. C. Teixeira, James A. Render
    Pages 267-289

  13. Nanoparticles for Drug and Gene Delivery in Treating Diseases of the Eye

    • Shreya S. Kulkarni, Uday B. Kompella
    Pages 291-316

  14. Back Matter

    Pages 317-323
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Keywords

About this book

Covering ocular pharmacokinetics, pharmacodynamics, and toxicology, Ocular Pharmacology and Toxicology provides ophthalmologists, toxicologists, and pharmacologists with both an introduction to the proper methods for ocular pharmacology and toxicology as well as providing practical methodologies for conducting ocular studies. Expert authors have contributed detailed chapters on study design, analysis, and routes to regulatory approval for various types and routes of ophthalmic drugs. As a volume in the Methods in Pharmacology and Toxicology series, chapters feature the kind of in-depth specifics and implementation advice to ensure successful results.

Practical and authoritative, Ocular Pharmacology and Toxicology serves as an ideal basis of training in the proper design and conduct of essential studies to accurately determine pharmacokinetics and ocular toxicity from the systemic, topical, periocular, or intraocular administration of drugs or compounds, from the use of ocular medical devices and from ocular surgical procedures.

Editors and Affiliations

  • Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, USA

    Brian C. Gilger

Bibliographic Information

  • Book Title: Ocular Pharmacology and Toxicology

  • Editors: Brian C. Gilger

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-62703-745-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-62703-744-0Published: 28 November 2013

  • Softcover ISBN: 978-1-4939-6069-9Published: 17 September 2016

  • eBook ISBN: 978-1-62703-745-7Published: 08 July 2014

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: X, 323

  • Number of Illustrations: 36 b/w illustrations, 54 illustrations in colour

  • Topics: Pharmacology/Toxicology

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