Editors:
- Provides updated variations on assays as well as numerous new protocols for drug discovery optimization
- Features readily reproducible methods and protocols that are lab-tested and successful
- Includes expert tips and key implementation advice
Part of the book series: Methods in Pharmacology and Toxicology (MIPT)
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Table of contents (34 protocols)
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Front Matter
About this book
Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.
Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.
Editors and Affiliations
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CREATe Core Science Technologies, Janssen Research & Development, LLC, Spring House, USA
Gary W. Caldwell, Zhengyin Yan
Bibliographic Information
Book Title: Optimization in Drug Discovery
Book Subtitle: In Vitro Methods
Editors: Gary W. Caldwell, Zhengyin Yan
Series Title: Methods in Pharmacology and Toxicology
DOI: https://doi.org/10.1007/978-1-62703-742-6
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-62703-741-9Published: 09 November 2013
Softcover ISBN: 978-1-4939-6070-5Published: 23 August 2016
eBook ISBN: 978-1-62703-742-6Published: 08 November 2013
Series ISSN: 1557-2153
Series E-ISSN: 1940-6053
Edition Number: 2
Number of Pages: XVII, 597
Number of Illustrations: 64 b/w illustrations, 49 illustrations in colour
Topics: Pharmacology/Toxicology