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Teratogenicity Testing

Methods and Protocols

Editors:

  • Provides extensive tips and guidance on how to deal with unexpected results and how to overcome difficulties
  • Features clear, complete instructions with each method
  • Serves as a comprehensive guide to methods of safety testing of all classes of chemical for teratogenicity
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 947)

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Table of contents (36 protocols)

  1. Front Matter

    Pages i-xiv
  2. The Developmental Toxicity Testing of Biologics

    • Keith P. Hazelden
    Pages 31-36
  3. Teratology Testing Under REACH

    • Steve Barton
    Pages 57-72
  4. The Teratology Testing of Food Additives

    • Paul C. Barrow, François Spézia
    Pages 73-80
  5. Developmental Toxicity Testing of Vaccines

    • Paul C. Barrow, Linda Allais
    Pages 81-89
  6. The Teratology Testing of Cosmetics

    • François Spézia, Paul C. Barrow
    Pages 91-94
  7. Teratology Studies in the Rat

    • Mariline Leroy, Linda Allais
    Pages 95-109
  8. Teratology Studies in the Mouse

    • Edward Marsden, Mariline Leroy
    Pages 111-123
  9. Combined Fertility and Embryotoxicity Study

    • Lucie Reynaud, Edward Marsden
    Pages 125-137
  10. Teratology Studies in the Rabbit

    • Linda Allais, Lucie Reynaud
    Pages 139-156
  11. Teratology Studies in the Minipig

    • Peter A. McAnulty
    Pages 157-167
  12. Embryo fetal Development Studies in Nonhuman Primates

    • Antje Fuchs, Eberhard Buse, Gerhard F. Weinbauer
    Pages 169-183
  13. The Enhanced Pre- and Postnatal Development Study for Monoclonal Antibodies

    • Gerhard F. Weinbauer, Joerg Luft, Antje Fuchs
    Pages 185-200
  14. Skeletal Examination by Alizarin Staining

    • Lucie Reynaud, Audrey Jocteur-Monrozier
    Pages 201-213
  15. Small Animal Imaging and Examination by Micro-CT

    • Sergio X. Vasquez, Neha Shah, Alan M. Hoberman
    Pages 223-231

About this book

Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular Biologyâ„¢ series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.

Editors and Affiliations

  • CiToxLAB, Evreux, France

    Paul C. Barrow

Bibliographic Information

  • Book Title: Teratogenicity Testing

  • Book Subtitle: Methods and Protocols

  • Editors: Paul C. Barrow

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-62703-131-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2013

  • Hardcover ISBN: 978-1-62703-130-1Published: 09 November 2012

  • Softcover ISBN: 978-1-4939-6250-1Published: 23 August 2016

  • eBook ISBN: 978-1-62703-131-8Published: 09 November 2012

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 601

  • Topics: Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 179.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access