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TRP Channels in Drug Discovery

Volume II

  • Book
  • © 2012

Overview

Editors:
  1. Arpad Szallasi

    1. Transfusion Services, Monmouth Medical Center, Long Branch, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Tamás Bíró

    1. Department of Physiology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Features lab-ready protocols on TRPs and cardiovascular, brain, skin, and metabolic issues, among other disorders
  • Includes clear and concise methodologies
  • Contains expert tips and vital implementation advice to ensure successful results

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (28 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. TRPs and Cardiovascular Disease

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. TRPs to Cardiovascular Disease

      • José C. González-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon, Mohamed Trebak
      Pages 3-40

    3. Anemic Zebrafish Models of Cardiomyopathy

      • Xiaojing Sun, Xiaolei Xu
      Pages 41-54

    4. Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function

      • Yan Ma, Yung-Wui Tjong, Xiaoqiang Yao
      Pages 55-74

    5. Atherosclerosis Models with Cell-Mediated Calcification

      • Beili Zhu
      Pages 75-90

    6. Models of Hypertension and Blood Pressure Recording

      • Luciana Aparecida Campos, Ovidiu Constantin Baltatu
      Pages 91-99

    7. Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling

      • Wei Zhang, Mohamed Trebak
      Pages 101-111

  3. TRPs and the Brain

    1. Front Matter

      Pages 113-113
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    2. TRP Channels in the Brain

      • Antonio Reboreda
      Pages 115-140

    3. Investigation of the Possible Role of TRP Channels in Schizophrenia

      • Loris A. Chahl
      Pages 141-151

    4. Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish

      • Amanda Decker, Robert Cornell
      Pages 153-166

    5. A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents

      • Caitlin J. Riebe, Carsten T. Wotjak
      Pages 167-185

    6. Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory

      • Jennifer L. McGuire, Jennifer L. Coyner, Luke R. Johnson
      Pages 187-202

    7. Chick Anxiety–Depression Screening Model

      • Stephen W. White, Kenneth J. Sufka
      Pages 203-210

    8. A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat

      • Ryan C. Turner, Alisa S. Elliott, Jason D. Huber, Charles L. Rosen
      Pages 211-229

    9. Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies

      • Koji Shibasaki
      Pages 231-237

    10. Methods in Neuronal Growth Cone Biology

      • Robert J. Gasperini, Lisa Foa
      Pages 239-252

  4. TRPs and Skin

    1. Front Matter

      Pages 253-253
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    2. Transient Receptor Potential Channels and Pruritus

      • Heike Benecke, Janine Wäring, Tobias Lotts, Sonja Ständer
      Pages 255-277
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Keywords

About this book

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.

 

Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

Editors and Affiliations

  • Transfusion Services, Monmouth Medical Center, Long Branch, USA

    Arpad Szallasi

  • Department of Physiology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

    Tamás Bíró

Bibliographic Information

  • Book Title: TRP Channels in Drug Discovery

  • Book Subtitle: Volume II

  • Editors: Arpad Szallasi, Tamás Bíró

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-62703-095-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-62703-094-6

  • Softcover ISBN: 978-1-4939-6066-8

  • eBook ISBN: 978-1-62703-095-3

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XIV, 489

  • Topics: Pharmacology/Toxicology, Proteomics

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