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TRP Channels in Drug Discovery

Volume I

  • Book
  • © 2012

Overview

Editors:
  1. Arpad Szallasi

    1. , Transfusion Services, Monmouth Medical Center, Long Branch, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Tamás Bíró

    1. Medical and Health Science Center, Department of Physiology, University of Debrecen, Debrecen, Hungary

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Features reviews of the most interesting TRP channels, from TRPA1 to TRPV4
  • Includes clear and focused protocols on TRP channels and disorders of airways and the GU tract
  • Contains important implementation tips for the lab-ready, tested protocols
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (21 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  3. TRP Channels, from A1 to V4

    1. Front Matter

      Pages 41-41
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    2. TRPA1 in Drug Discovery

      • Jun Chen, Steve McGaraughty, Philip R. Kym
      Pages 43-59

    3. Canonical Transient Receptor Potential Channel Expression, Regulation, and Function in Vascular and Airway Diseases

      • Brij B. Singh, Christina M. Pabelick, Y. S. Prakash
      Pages 61-87

    4. TRPM2 Function and Potential as a Drug Target

      • Barbara A. Miller
      Pages 89-102

    5. The Ca2+-Activated Monovalent Cation-Selective Channels TRPM4 and TRPM5

      • Barbara Colsoul, Miklos Kecskes, Koenraad Philippaert, Aurelie Menigoz, Rudi Vennekens
      Pages 103-125

    6. The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis

      • Vladimir Chubanov, Jonathan T. Eggenschwiler, Lillia V. Ryazanova, Thomas Gudermann, Alexey G. Ryazanov
      Pages 127-139

    7. TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation

      • David D. McKemy
      Pages 141-158

    8. TRPML Channels in Function, Disease, and Prospective Therapies

      • David A. Zeevi
      Pages 159-191

    9. The TRPP Signaling Module: TRPP2/Polycystin-1 and TRPP2/PKD1L1

      • Alexis Hofherr
      Pages 193-219

    10. TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities

      • Olivier Radresa, Stephen Zicha, William Brown, Jennifer M. A. Laird
      Pages 221-235

    11. Nociceptive and Nonnociceptive Roles of TRPV3 and Its “Druggability”

      • Sungjae Yoo, Sun Wook Hwang
      Pages 237-256

    12. TRPV4 and Drug Discovery

      • Fabien Vincent, Matthew A. J. Duncton
      Pages 257-270

  4. TRPs and Airways

    1. Front Matter

      Pages 271-271
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    2. TRP Expression and Function in the Lung Airways

      • Alexander Dietrich, Thomas Gudermann
      Pages 273-282

    3. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells

      • Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, Alexander Dietrich
      Pages 283-300

    4. Endotoxin-Induced Airway Inflammation and Asthma Models

      • Zsuzsanna Helyes, Zsófia Hajna
      Pages 301-342
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Keywords

About this book

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.

 

Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

Editors and Affiliations

  • , Transfusion Services, Monmouth Medical Center, Long Branch, USA

    Arpad Szallasi

  • Medical and Health Science Center, Department of Physiology, University of Debrecen, Debrecen, Hungary

    Tamás Bíró

Bibliographic Information

  • Book Title: TRP Channels in Drug Discovery

  • Book Subtitle: Volume I

  • Editors: Arpad Szallasi, Tamás Bíró

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-62703-077-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-62703-076-2Published: 20 September 2012

  • Softcover ISBN: 978-1-4939-6281-5Published: 23 August 2016

  • eBook ISBN: 978-1-62703-077-9Published: 20 September 2012

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XI, 446

  • Topics: Pharmacology/Toxicology, Proteomics

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