Editors:
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 902)
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Table of contents (19 protocols)
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Front Matter
About this book
Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.
Reviews
From the book reviews:
“This is a compilation of LC-MS/MS technical procedures for drug analysis. … It is written for practicing toxicologists or clinical chemists whose daily practice includes analysis for these clinically important substances. It also would be of interest to anyone curious about clinical laboratory testing for any of these compounds or interested in clinical applications of LC-MS/MS. … You will need this book if you are involved in LC-MS/MS analysis for compounds of clinical interest.” (Valerie L. Ng, Doody’s Book Reviews, November, 2012)Editors and Affiliations
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Mayo Clinic, Rochester, USA
Loralie J. Langman, Christine L. H. Snozek
Bibliographic Information
Book Title: LC-MS in Drug Analysis
Book Subtitle: Methods and Protocols
Editors: Loralie J. Langman, Christine L. H. Snozek
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-61779-934-1
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC 2012
Hardcover ISBN: 978-1-61779-933-4Published: 06 July 2012
Softcover ISBN: 978-1-4939-6199-3Published: 23 August 2016
eBook ISBN: 978-1-61779-934-1Published: 06 July 2012
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: X, 224