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Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

  • Book
  • © 2012

Overview

Editors:
  1. Antonio Russo

    1. Department of Surgical and, Oncological Sciences, University of Palermo, Palermo, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Stefano Iacobelli

    1. , National Consortium for Research on, University D’Annunzio, Chieti, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. Juan Iovanna

    1. INSERM U624, Marseille, France

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    You can also search for this editor in PubMed   Google Scholar

  • Presents a range of applications for oncological disease
  • Useful and comprehensive resource
  • Written by international opinion leaders in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Clinical Pathology (CCPATH)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi
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  2. Gene Signatures and Soft Tissue Sarcomas: Status of Art and Perspectives

    • Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, Giuseppe Tonini
    Pages 1-11

  3. Heterogeneity of Breast Cancer: Gene Signatures and Beyond

    • Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, John W. M. Martens
    Pages 13-25

  4. Gene Signatures in CRC and Liver Metastasis

    • Daniele Fanale, Lidia Corsini, Sergio Rizzo, Antonio Russo
    Pages 27-33

  5. Gene Signatures in Gastrointestinal Stromal Tumors

    • Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna PrzybyĹ‚, Maria Debiec-Rychter
    Pages 35-50

  6. Pancreatic Cancer Genetics

    • Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, Nelson Dusetti
    Pages 51-79

  7. Diagnostic, Prognostic, and Therapeutic Value of Gene Signatures in Non-Small Cell Lung Cancer

    • Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, Jia Wei
    Pages 81-94

  8. Gene Signatures in Gastric Cancer

    • Laura Ottini, Mario Falchetti, Gabriella Nesi
    Pages 95-113

  9. Gene Signatures in Colorectal Cancer

    • Alessandro Lugli, Inti Zlobec
    Pages 115-136

  10. The Role of Epigenetics in Cancer: From Molecular Function to High-Throughput Assays

    • Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, Salvatore Spicuglia
    Pages 137-152

  11. Primary Epithelial Ovarian Neoplasms: New Concepts Concerning Origin, Pathogenesis and Classification Based on Morphology, Immunomarkers, Molecular Features, and Gene Expression Studies

    • Bernard Czernobilsky, Leonor Leider-Trejo, Daniele Fanale, Antonio Russo
    Pages 153-164

  12. Thyroid Carcinoma: Molecular Signature by Histotype-Specific Mutations and Gene Expression Patterns

    • Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, Giancarlo Troncone
    Pages 165-178

  13. Back Matter

    Pages 179-182
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About this book

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.

 

Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.

 

Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Reviews

From the reviews:

“This is a useful compendium of various molecular methods (with a special focus on microarray technology) applied to research and diagnostic and prognostic purposes for most solid human tumors … . The book is designed primarily for residents and fellows, oncologists, pathologists, molecular biologists, biotechnologists, and others who study oncologic diseases. … chapters are detailed and informative and present molecular genetic aspects in an appropriate clinical setting. … The references following each chapter are extensive, relevant, and updated.” (Semir Vranic, Doody’s Review Service, July, 2012)

Editors and Affiliations

  • Department of Surgical and, Oncological Sciences, University of Palermo, Palermo, Italy

    Antonio Russo

  • , National Consortium for Research on, University D’Annunzio, Chieti, Italy

    Stefano Iacobelli

  • INSERM U624, Marseille, France

    Juan Iovanna

Bibliographic Information

  • Book Title: Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

  • Editors: Antonio Russo, Stefano Iacobelli, Juan Iovanna

  • Series Title: Current Clinical Pathology

  • DOI: https://doi.org/10.1007/978-1-61779-358-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-61779-357-8Published: 02 November 2011

  • Softcover ISBN: 978-1-4939-6259-4Published: 23 August 2016

  • eBook ISBN: 978-1-61779-358-5Published: 03 November 2011

  • Series ISSN: 2197-781X

  • Series E-ISSN: 2197-7828

  • Edition Number: 1

  • Number of Pages: XI, 182

  • Number of Illustrations: 4 b/w illustrations, 24 illustrations in colour

  • Topics: Pathology, Oncology, Laboratory Medicine

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