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Signal Transduction and the Gasotransmitters

NO, CO, and H2S in Biology and Medicine

  • Book
  • © 2004

Overview

Editors:
  1. Rui Wang

    1. Department of Physiology, University of Saskatchewan, Saskatoon, Canada

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Gasotransmitters: Past, Present, and Future

    1. Front Matter

      Pages 1-1
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    2. The Evolution of Gasotransmitter Biology and Medicine

      • Rui Wang
      Pages 3-31

    3. Interactions Between Gasotransmitters

      • Ray J. Carson, Gunter Seyffarth, Rubina Mian, Helen Maddock
      Pages 33-55

  3. The Emergence of the First Gasotransmitter: Nitric Oxide

    1. Front Matter

      Pages 57-57
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    2. Nitric Oxide

      • Chris R. Triggle, Hong Ding, Ella S. M. Ng, Anthie Ellis
      Pages 59-94

    3. Chemical Interaction of Nitric Oxide With Protein Thiols

      • Allan Doctor, Benjamin M. Gaston
      Pages 95-107

    4. Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels

      • Shoji Sanada, Jiyoong Kim, Masafumi Kitakaze
      Pages 109-122

    5. Interaction of Nitric Oxide and Related Radical Species With KCa Channels

      • Yanping Liu, David D. Gutterman
      Pages 123-136

    6. Nitric Oxide and Voltage-Gated Ca2+ Channels

      • Claudio Grassi, Marcello D’Ascenzo, Gian Battista Azzena
      Pages 137-155

    7. Interactions of Nitric Oxide and Cardiac Ion Channels

      • Zhao Zhang, Kathryn A. Glatter, Nipavan Chiamvimonvat
      Pages 157-168

    8. S-Nitrosylation of Cyclic Nucleotide-Gated Channels

      • Marie-Christine Broillet
      Pages 169-183

  4. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter

    1. Front Matter

      Pages 185-185
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    2. Synthesis and Metabolism of Carbon Monoxide

      • Stefan W. Ryter, Augustine M. K. Choi
      Pages 187-203

    3. Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells

      • Rui Wang
      Pages 205-218

    4. Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells

      • Rui Wang
      Pages 219-230

    5. The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels

      • Lingyun Wu
      Pages 231-247

    6. Carbon Monoxide and Signal Transduction Pathways

      • Patty J. Lee, Leo E. Otterbein
      Pages 249-258

    7. Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells

      • Eric Dubuis, Prem Kumar, Pierre Bonnet, Christophe Vandier
      Pages 259-272

  5. Gas of the Rotten Egg: Hydrogen Sulfide as the Third Gasotransmitter

    1. Front Matter

      Pages 273-273
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Keywords

About this book

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters.
Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

Reviews

From the foreword...
"...a paradigm-shifting assessment of the new category of transmitters, the gasotransmitters."
-Bruce McManus, MD, PhD, FRSC, Canadian Institutes of Health Research

"...well-written...the account by Sanada and colleagues is particularly interesting on cardio protection and ischeamic preconditioning...this book should be of interest to both specialist researchers as well as members of the wider scientific commuity." -BTS Newsletters

"...an excellent source of references for signal transduction mechanisms underlying he physiological functions of NO, CO, and H2S." - British Journal of Anesthesiology

Editors and Affiliations

  • Department of Physiology, University of Saskatchewan, Saskatoon, Canada

    Rui Wang

Bibliographic Information

  • Book Title: Signal Transduction and the Gasotransmitters

  • Book Subtitle: NO, CO, and H2S in Biology and Medicine

  • Editors: Rui Wang

  • DOI: https://doi.org/10.1007/978-1-59259-806-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-58829-349-7Published: 11 June 2004

  • Softcover ISBN: 978-1-61737-512-5Published: 05 November 2010

  • eBook ISBN: 978-1-59259-806-9Published: 11 June 2004

  • Edition Number: 1

  • Number of Pages: XIV, 378

  • Topics: Medicine/Public Health, general, Life Sciences, general, Biochemistry, general

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