DNA Repair in Cancer Therapy

1. Front Matter

   Pages i-xi

   PDF

2. Clinical Resistance to Alkylators

   • Brian Leyland-Jones

   Pages 1-7

3. Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents

   • Lawrence C. Panasci, Zhi-Yuan Xu, Raquel Aloyz

   Pages 9-29

4. Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs

   • Peter J. McHugh, John A. Hartley

   Pages 31-49

5. Chemosensitization to Platinum-Based Anticancer Drugs

   • Bertrand J. Jean-Claude

   Pages 51-71

6. Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells

   • Istvan Boldogh, Kishor K. Bhakat, Dora Bocangel, Gokul C. Das, Sankar Mitra

   Pages 73-108

7. Stress-Activated Signal Transduction Pathways in DNA Damage Response

   • Moulay A. Alaoui-Jamali, P. James Scrivens, Martin Loignon

   Pages 109-141

8. Overcoming Resistance to Alkylating Agents by Inhibitors of O ⁶-Alkylguanine-DNA Alkyltransferase

   • Anthony E. Pegg, M. Eileen Dolan

   Pages 143-169

9. Cellular Protection Against the Antitumor Drug Bleomycin

   • Dindial Ramotar, Huijie Wang, Chaunhua He

   Pages 171-196

10. Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death

    • Michèle Rouleau, Guy G. Poirier

    Pages 197-210

11. Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy

    • David Murray, Adrian C. Begg

    Pages 211-256

12. Strand-Break Repair and Radiation Resistance

    • George Shenouda

    Pages 257-272

13. V(D)J Recombination and DNA Double-Strand-Break Repair

    • Despina Moshous, Jean-Pierre de Villartay

    Pages 273-293

14. Inherited Disorders of Genomic Instability and Cancer Susceptibility

    • Gary M. Kupfer

    Pages 295-321

15. Role of BRCA1 and BRCA2 in DNA Repair and Potential Impact on Therapeutics

    • Razqallah Hakem

    Pages 323-337

16. Genetic Variations in DNA Repair

    • Jennifer J. Hu

    Pages 339-351

17. Back Matter

    Pages 353-363

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A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

• BRCA
• DNA
• apoptosis
• cancer treatment
• cell
• cell death
• clinical trial
• prevention
• radiotherapy
• tumor
• tumorigenesis

...gives a comprehensive review of the modern status of the DNA repair field for cancer researchers and clinical practitioners and provides a solid basis for in-depth study of different areas in this field...The book is a timely publication with a significant intended audience that will be served well. The book is well planned, well written, comprehensive, and addresses recent findings in the field. -Doody's Health Sciences Book Review Journal

"...extensive and extremely detailed...a comprehensive review of DNA repair." - The Annals of Pharmacotherapy

"Comprehensive and cutting-edge, for both cancer researchers and practicing oncologists dealing with the hallmark 'relapse; or 'drug resistance' phenomena on a daily basis...." Tumori

• Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Canada

  Lawrence C. Panasci, Moulay A. Alaoui-Jamali

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