The Melanocortin Receptors

1. Front Matter

   Pages i-x

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2. Historical Perspectives

   1. Front Matter

      Pages 1-1

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   2. Proopiomelanocortin and the Melanocortin Peptides

      • Alex N. Eberle

      Pages 3-67

   3. Melanocortins and Pigmentation

      • Aaron B. Lerner

      Pages 69-73

   4. Melanocortins and Adrenocortical Function

      • Martine Bégeot, José M. Saez

      Pages 75-107

   5. Effects of Melanocortins in the Nervous System

      • Roger A. H. Adan

      Pages 109-141

   6. Peripheral Effects of Melanocortins

      • Bruce A. Boston

      Pages 143-169

3. Characterization of the Melanocortin Receptors

   1. Front Matter

      Pages 171-171

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   2. Melanocortin Receptor Expression and Function in the Nervous System

      • Jeffrey B. Tatro

      Pages 173-207

   3. Cloning of the Melanocortin Receptors

      • Kathleen G. Mountjoy

      Pages 209-235

4. Biochemical Mechanism of Receptor Action

   1. Front Matter

      Pages 237-237

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   2. The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone

      • Victor J. Hruby, Guoxia Han

      Pages 239-261

   3. In Vitro Mutagenesis Studies of Melanocortin Receptor Coupling and Ligand Binding

      • Carrie Haskell-Luevano

      Pages 263-306

5. Receptor Function

   1. Front Matter

      Pages 307-307

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   2. The Melanocortin-1 Receptor

      • Dongsi Lu, Carrie Haskell-Luevano, Dag Inge Vage, Roger D. Cone

      Pages 309-339

   3. The Human Melanocortin-1 Receptor

      • Eugene Healy, Mark Birch-Machin, Jonathan L. Rees

      Pages 341-359

   4. The Melanocortin-2 Receptor in Normal Adrenocortical Function and Familial Adrenocorticotropic Hormone Resistance

      • Adrian J. L. Clark

      Pages 361-383

   5. The Melanocortin-3 Receptor

      • Robert A. Kesterson

      Pages 385-403

   6. The Melanocortin-4 Receptor

      • Roger D. Cone

      Pages 405-447

   7. The Melanocortin-5 Receptor

      • Wenbiao Chen

      Pages 449-472

Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. The book illuminates the structure and function of these receptors through a wide-ranging review of the latest findings concerning the biology, physiology, and pharmacology of their peptide ligands and covers the major melanocortin peptides, Melanocortin-1-Receptors through Melanocortin-5-Receptors. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation. Timely and authoritative, The Melanocortin Receptors offers an up-to-date knowledge base on the remarkably complex structure and functions of the melanocortins, a guide that will prove invaluable for today's neuroscientists, endocrinologists, pharmacologists, and other clinical and experimental investigators working in this fast moving field.

• Nervous System
• base
• biology
• hormone
• hormone resistance
• melanoma
• mutagenesis
• pharmacology
• physiology
• receptor
• resistance

"New data on melanocortin receptors 1-5 and their regulation are the topic of several chapters. A complete, well referenced text of interest to all endocrinologists, neuroscientists, geneticists, physiologists and pharmacologists." - Journal of Pediatric Endocrinology & Metabolism

• Vollum Institute, Oregon Health Sciences University, Portland, USA

  Roger D. Cone

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