The Opiate Receptors

1. Front Matter

   Pages i-xviii

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2. Historical Perspectives

   1. Front Matter

      Pages 1-1

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   2. The Evolution of Concepts of Opioid Receptors

      • W. R. Martin

      Pages 3-22

   3. The Opioid Peptides

      • Christopher J. Evans, Donna L. Hammond, Robert C. A. Frederickson

      Pages 23-71

3. Characterization of Opioid Receptor Binding Sites

   1. Front Matter

      Pages 73-73

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   2. Early Studies of Opioid Binding

      • Gavril W. Pasternak

      Pages 75-93

   3. Multiple Opioid Binding Sites

      • Yossef Itzhak

      Pages 95-142

   4. The σ Receptor

      • R. Suzanne Zukin, Stephen R. Zukin

      Pages 143-163

   5. Solubilization and Purification of Opioid Binding Sites

      • Eric J. Simon, Jacob M. Hiller

      Pages 165-194

4. Location of Opioid Receptors

   1. Front Matter

      Pages 195-195

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   2. Regional Distribution of Opioid Receptors

      • Robert R. Goodman, Benjamin A. Adler, Gavril W. Pasternak

      Pages 197-228

5. Mechanisms of Receptor Action

   1. Front Matter

      Pages 229-229

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   2. Opioid-Coupled Second Messenger Systems

      • Steven R. Childers

      Pages 231-271

   3. Electrophysiology of Opiates and Opioid Peptides

      • Charles Chavkin

      Pages 273-303

6. Pharmacological Correlation of Binding Sites with Function

   1. Front Matter

      Pages 305-305

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   2. Central Actions of Opiates and Opioid Peptides

      • Paul L. Wood, Smriti Iyengar

      Pages 307-356

   3. Peripheral Actions Mediated by Opioid Receptors

      • Brian M. Cox

      Pages 357-422

7. Regulation of Opioid Receptors

   1. Front Matter

      Pages 423-423

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   2. Regulation of Opioid Receptors

      • Steven G. Blanchard, Kwen-Jen Chang

      Pages 425-439

   3. Role of Opioid Receptors in Narcotic Tolerance/ Dependence

      • Andrew P. Smith, Ping-Yee Law, Horace H. Loh

      Pages 441-485

The growth of the opiate field over the past decade has been enor­ mous. Initial interest focused upon the strategic clinical impor­ tance of morphine and its analogs, but the discovery of the enkephalins and the other endogenous opioid peptides with their widespread actions within brain has expanded the field to investi­ gators in almost all areas of neuroscience as well as pharmacol­ ogy. Unfortunately, this field of research with its vast literature has become progressively more complex. The receptors are no longer limited to opiates, but include many subtypes selective for the opioid peptides. Indeed, they might be better termed opioid, rather than opiate, receptors. Many controversies have emerged and been settled; others remain. Early studies must now be inter­ preted on the basis of current information. Thousands of papers examining various aspects of opiates and the endogenous opioids present separate pieces of a large puzzle. The goal of this volume is to put the pieces together to give a coherent overview of opiate receptor pharmacology and to provide insights into both the mo­ lecular and classical pharmacology of opiates and the opioid pep­ tides. The issue of multiple classes of opiate and opioid peptide re­ ceptors and their importance in understanding mechanisms of ac­ tion provides the major focus of the book. The study of opiates and opioid peptides provides a unique research opportunity in the neuropharmacology of drug receptors.

• brain
• drug
• endogenous opioid peptides
• neuropharmacology
• neuroscience
• opioid
• receptor
• research

• Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, USA

  Gavril W. Pasternak

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