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Animal Models of Dementia

  • Book
  • © 2011

Overview

Editors:
  1. Peter Paul De Deyn

    1. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Wilrijk, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  2. Debby Van Dam

    1. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Wilrijk, Belgium

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Appeals to a broad readership from neuropathologists, pharmacists, biochemists, and biologists to clinical neurologists
  • Features a large, comprehensive section on Alzheimer’s disease
  • Includes contributions from prominent investigators sharing their experience through detailed, easily accessible methods
  • Includes supplementary material: sn.pub/extras

Part of the book series: Neuromethods (NM, volume 48)

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Table of contents (34 protocols)

  1. Front Matter

    Pages i-xv
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  2. Animal Modeling: General and Ethical Aspects and Drug Discovery Pipeline

    1. Front Matter

      Pages 1-1
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    2. General Introduction to Animal Models of Human Conditions

      • Peter Paul De Deyn, Debby Van Dam
      Pages 3-13

    3. Animal Models of Dementia: Ethical Considerations

      • I. Anna S. Olsson, Peter Sandøe
      Pages 15-33

    4. The Role of Rodent Models in the Drug Discovery Pipeline for Dementia

      • Debby Van Dam, Peter Paul De Deyn
      Pages 35-49

  3. Methodological Considerations when Developing Animal Models of Dementia

    1. Front Matter

      Pages 51-51
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    2. Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia

      • Annemie Van Dijck, Debby Van Dam, Peter Paul De Deyn
      Pages 53-75

    3. Transgenic and Gene Targeted Models of Dementia

      • Ronald A. Conlon
      Pages 77-90

    4. Transgenic Animals and Intellectual Property Concerns

      • Susan L. Stoddard, James A. Rogers III
      Pages 91-96

  4. Validation of Animal Models of Dementia

    1. Front Matter

      Pages 97-97
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    2. Pathological Validation of Animal Models of Dementia

      • Daniel Pirici, Christine Van Broeckhoven, Samir Kumar-Singh
      Pages 99-141

    3. Behavioral Validation in Animal Models of Dementia

      • Debby Van Dam, Annemie Van Dijck, Peter Paul De Deyn
      Pages 143-154

    4. Pharmacological Validation in Animal Models of Dementia

      • Hugo Geerts
      Pages 155-168

    5. Validation of Animal Models of Dementia: Neurochemical Aspects

      • Giancarlo Pepeu, Maria Cristina Rosi
      Pages 169-185

    6. Validation of Dementia Models Employing Neuroimaging Techniques

      • Greet Vanhoutte, Adriaan Campo, Annemie Van der Linden
      Pages 187-220

  5. Animal Models of Alzheimer’s Disease

    1. Front Matter

      Pages 221-221
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    2. Drosophila Melanogaster as a Model Organism for Dementia

      • Maria E. Giannakou, Damian C. Crowther
      Pages 223-240

    3. Caenorhabditis elegans as a Model Organism for Dementia

      • Tjakko J. Van Ham, Ellen A. A. Nollen
      Pages 241-253

    4. Zebrafish (Danio rerio) as a Model Organism for Dementia

      • Rob Willemsen, Sandra van’t Padje, John C. van Swieten, Ben A. Oostra
      Pages 255-269

    5. Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively Bred Strains (SAM Strains)

      • Renã A. Sowell, D. Allan Butterfield
      Pages 271-293
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Keywords

About this book

With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Reviews

From the book reviews:

“A complete guide to lesion induced, genetic knockout, and phylogenetic approaches to dementias is catalogued. … I recommend this book for animal researcher for sure, and neurologists in particular.” (Joseph J. Grenier, Amazon.com, August, 2014)

“A great add-on to more basic textbooks on mechanisms of dementia. The book not only nicely summarizes ongoing efforts to model dementia but also describes how to investigate underlying mechanisms at various level of complexity. … Importantly, leading mouse models are discussed, which is very useful for newcomers to the field, as there are a lot of different models. … Additionally, the book provides information about ethics on animal experimentation and information on intellectual property, issues that can be rarely found in textbooks.” (Karl Peter Giese, British Journal of Clinical Pharmacology, May, 2011)

Editors and Affiliations

  • Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Wilrijk, Belgium

    Peter Paul De Deyn, Debby Van Dam

Bibliographic Information

  • Book Title: Animal Models of Dementia

  • Editors: Peter Paul De Deyn, Debby Van Dam

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-60761-898-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-60761-897-3Published: 01 December 2010

  • Softcover ISBN: 978-1-4939-6118-4Published: 23 August 2016

  • eBook ISBN: 978-1-60761-898-0Published: 17 December 2010

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XV, 732

  • Topics: Neurosciences, Neurology, Animal Models

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