Microarray Methods for Drug Discovery

While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital applications. Covering the field of drug discovery through its various aspects, including high throughput screening, target identification, drug metabolism and toxicity screening as well as clinical sample handling, this volume also addresses new emerging fields like miRNA profiling, ribonomic and glycomic profiling. All chapters, contributed by experts in the field, follow the highly successful Methods in Molecular Biology™ series format, which is comprised of brief introductions, lists of required materials and reagents, readily reproducible, step-by-step lab protocols, along with detailed tips on troubleshooting and avoiding known pitfalls, making this book an easy read for investigators at all levels of expertise.

Authoritative and cutting-edge, Microarray Methods for Drug Discovery provides an ideal desk reference for scientists who wish to use microarray technology in order to better understand a variety of biological interactions in their respective fields.

• Antibodies
• Cytogenetics
• DNA
• DNA oligonucleotides
• Drug metabolism
• PCR
• Personalized medicine
• Regulation
• Small molecules
• Termination
• gene expression
• genetics
• miRNA profiling
• tissue
• transcription

From the reviews:

“Microarray Methods for Drug Discovery is volume number 632 of the Springer Protocols Methods in Biology Series. … it provides detailed experimental protocols for the use of microarrays in a variety of applications. … chapters are obviously highly bespoke and would be of real value to laboratories wishing to establish the method. Finally, the microarray area is now so broad that the non-nucleic acid application of microarrays would justify a methods book in its own right.” (James Sidaway, BTS Newsletter, Issue 37, Winter, 2010)

“Methods in Microarrays provide scientists with a complete resource on the most effective tools available for maximizing microarray data in biochemical methods. … Microarrays are extensively used in the effects of compounds on gene expression in cells. This book aims at enlightening individuals of all levels of experience about some of the most common applications of microarrays in drug discovery and development. This book will serve as a reference for students and scientists … .” (Veni Maria Andres Felli, Brazilian Journal of Pharmaceutical Sciences, May, 2010)

• Department of Biomedical Sciences Schools of Public Health Centre for Functional Genomics, University at Albany-SUNY, Rensselaer, USA

  Sridar V. Chittur

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