Hypertension and Stroke

1. Front Matter

   Pages i-xiv

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2. Blood Pressure and Hypertension as Antecedents of Stroke

   1. Front Matter

      Pages 1-1

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   2. Blood Pressure: Definition, Diagnosis, and Management

      • Raymond R. Townsend, Susan P. Steigerwalt

      Pages 3-19

   3. The Link Between Hypertension and Stroke: Summary of Observational Epidemiological Studies

      • Youji Soga, Dilip K. Pandey

      Pages 21-39

   4. Blood Pressure Control and Primary Prevention of Stroke: Summary of Clinical Trial Data

      • William J. Elliott

      Pages 41-59

3. Mechanisms of Hypertension and Hypertension-Related Stroke

   1. Front Matter

      Pages 61-61

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   2. Mechanisms Underlying Essential Hypertension: Neurogenic and Nonneurogenic Contributors

      • Scott H. Carlson, J. Michael Wyss

      Pages 63-76

   3. Pathophysiology and Mechanisms Whereby Hypertension May Cause Stroke

      • Jinhao Han, Hee-Joon Bae, Lawrence K.S. Wong

      Pages 77-94

4. Management of Blood Pressure for First Stroke Prevention, Immediately after Acute Stroke, and for Recurrent Stroke Prevention

   1. Front Matter

      Pages 95-95

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5. Management of Blood Pressure for First Stroke Prevention,Immediately after Acute Stroke,and for Recurrent Stroke Prevention

   1. Cardiovascular Risk Assessment and Summary of Guidelines for the Management of Hypertension

      • Tamar Polonsky, George Bakris

      Pages 97-113

   2. Acute Blood Pressure Management After Ischemic Stroke

      • Venkatesh Aiyagari

      Pages 115-126

   3. Hypertensive Encephalopathy and Acute Blood Pressure Management After Hemorrhagic Stroke

      • Rebbeca A. Grysiewicz, Sean D. Ruland

      Pages 127-141

   4. Recurrent Stroke Prevention I: Diuretic and Angiotensin-Converting Enzyme Inhibitors (ACEIs) – The PROGRESS Trial

      • Thomas K.A. Linden, Geoffrey A. Donnan

      Pages 143-157

   5. Recurrent Stroke Prevention II: Angiotensin Receptor Blockers—The LIFE, MOSES, PRoFESS, and Other Trials

      • Venkatesh Aiyagari, Philip B. Gorelick

      Pages 159-171

   6. A Practical Guide to Recurrent Stroke Prevention

      • Laura Pedelty

      Pages 173-192

6. Mechanisms and Sequelae of Elevated Blood Pressure on Brain Function and Cognition

   1. Front Matter

      Pages 193-193

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   2. Vascular Cognitive Impairment and Alzheimer Disease: Are These Disorders Linked to Hypertension and Other Cardiovascular Risk Factors?

      • Fernando D. Testai, Philip B. Gorelick

      Pages 195-210

   3. Cerebral Small Vessel Disease, Hypertension, and Cognitive Function

      • Elizabeth K. Geary, David L. Nyenhuis

      Pages 211-224

   4. Cerebral Microbleeds, Small-Vessel Disease of the Brain, Hypertension, and Cognition

      • Anand Viswanathan, Hugues Chabriat, Steven M. Greenberg

      Pages 225-235

   5. Imaging Effects of Hypertension on the Brain: A Focus on New Imaging Modalities and Options

      • Deborah M. Little, Evan Schulze, Nilay Shah, Shanele McGowan

      Pages 237-255

This timely volume addresses the intimate pathophysiologic relationship between hypertension and cardiovascular disease. Hypertension is one of the most important global public health challenges, and its relationship to stroke and other catastrophic cerebrovascular diseases is an area of growing understanding. In this outstanding book, the editors and authors clearly and concisely synthesize our developing knowledge and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of other cerebrovascular risk factors. In addition to prescriptive measures for first stroke prevention, the book illuminates current regimens for care immediately after acute stroke and for the prevention of recurrent stroke. A unique section is dedicated to the exploration of the interaction between elevated blood pressure and brain function and cognition. The concluding chapter provides a resource towards optimizing the organization of stroke care. Hypertension and Stroke is of great utility for specialists in neurology and cardiovascular medicine and a valuable practical resource for all physicians caring for older adults and hypertensive patients.

• Blood pressure
• Hemorrhagic stroke
• Hypertension
• Ischemic stroke
• Stroke
• Thrombolytic therapy

From the reviews:

“This book is interesting and well written by authorities in their fields. References are of sufficient number, and the tables and figures are appropriate. … this book could find a place in the libraries of neurologists, intensivists, hypertension experts, primary care physicians, or public health specialists. The vast array of medical professionals involved in the diagnosis and treatment of hypertension and stroke is testimony to the broad appeal this book can have.” (Panayiotis N. Varelas, Journal of the American Medical Association, November, 2011)

“This book is one of a series on Clinical Hypertension and Vascular Disease edited by William B. White, an eminent authority on hypertension. … useful to academics planning to write papers on the topics covered, as a source of references.” (Canadian Journal of Neurological Sciences, September, 2011)

“The pathophysiology, epidemiology, diagnosis, and treatment of hypertension with respect to cerebrovascular disease, this book also reviews the management of hypertension in multiple settings such as in primary and secondary stroke prevention, acute ischemic and hemorrhagic stroke, and vascular cognitive impairment/dementia. … a broad audience that includes primary care physicians, neurologists, cardiologists, physician assistants, nurse practitioners, residents, medical students, epidemiologists, stroke and cardiovascular researchers, and public health specialists. … This book offers a fresh perspective on the relationship between these two common entities.” (Dan Capampangan, Doody's Book Reviews, March, 2011)

• College of Medicine, Dept. Neurology, University of Illinois, Chicago, USA

  Venkatesh Aiyagari

• University of Illinois, Department of Neurology and Rehabilitati, College of Medicine at Chicago, Chicago, USA

  Philip B. Gorelick

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