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Maternal Influences on Fetal Neurodevelopment

Clinical and Research Aspects

  • Book
  • © 2010

Overview

Editors:
  1. Andrew W. Zimmerman

    1. Kennedy Krieger Institute, Center for Autism and Related Disorders, Johns Hopkins University, Baltimore, USA

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  2. Susan L. Connors

    1. Massachusetts General Hospital for Child, Lurie Family Autism Center / LADDERS Cli, Lexington, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive and ground-breaking overview of maternal influences on fetal neurodevelopment Wide-ranging discussion of the gene-environment interplay on brain development within the intrauterine environment, covering such neurodevelopmental disorders as ADHD, autism, schizophrenia, bipolar disorder and obsessive-compulsive disorder Fosters better understanding and supports the call for further research into maternal and fetal mechanisms that lead to neurodevelopmental disorders

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xii
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  2. Brave New World: The Intrauterine Environment as the Biological Foundation for the Lifespan

    • Tonse N. K. Raju
    Pages 1-8

  3. In the Beginning

    • Janet A. DiPietro
    Pages 9-17

  4. Maternal Influences on the Developing Fetus

    • Janet A. DiPietro
    Pages 19-32

  5. Implications of Maternal Programming for Fetal Neurodevelopment

    • Laura M. Glynn
    Pages 33-53

  6. Maternal Thyroid Function During Pregnancy: Effects on the Developing Fetal Brain

    • Joanne F. Rovet, Karen A. Willoughby
    Pages 55-77

  7. Obstetric Factors Related to Perinatal Brain Injury

    • Christopher S. Ennen, Ernest M. Graham
    Pages 79-95

  8. Activation of the Maternal Immune System as a Risk Factor for Neuropsychiatric Disorders

    • Stephen E. P. Smith, Elaine Hsiao, Paul H. Patterson
    Pages 97-115

  9. Prenatal Infections and Schizophrenia in Later Life – Focus on Toxoplasma gondii

    • Robert Yolken, E. Fuller Torrey
    Pages 117-136

  10. Maternally Acting Alleles in Autism and Other Neurodevelopmental Disorders: The Role of HLA-DR4 Within the Major Histocompatibility Complex

    • William G. Johnson, Steven Buyske, Edward S. Stenroos, George H. Lambert
    Pages 137-160

  11. Back Matter

    Pages 161-166
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Keywords

About this book

Novel Approaches into the Origins of Neurodevelopmental Disorders: The Fetal Physiology Foundation Over the past two decades, autism, a neurodevelopmental disorder that is defined by behavior and was once believed to be rare, became recognized in increasing numbers of children and recently received distinction as an “epidemic” [1]. While numbers of affected children have steadily increased, our knowledge is still ins- ficient to explain autism’s diverse causes and broad range of presentations. Despite remarkable progress in research, available medical diagnostic testing applies only to a small minority of affected children. Thus, scientifically based explanations with which physicians can diagnose and treat the majority of children with autism and advise their parents are quite limited. Our society and scientific community were unprepared for the rise in autism, which explains our present inability to understand most of its causes. Researchers in neurodevelopmental disorders have long been aware of other disorders that, despite extensive efforts, have not yielded clear genetic or environmental origins, and autism has become symbolic of the need for new approaches to research into these complex conditions. Although autism has captured our attention in recent years, the prevalence of other neurodevelopmental disorders such as attention de- cit hyperactivity disorder (ADHD) and bipolar disorder, among others, also has been increasing [2–4].

Reviews

From the reviews:

“This interesting book examines an extremely pertinent topic in obstetrics, the gene-environment interplay and its effects on the developing human brain. … Clearly the authors have done a good job of reviewing relevant literature as well as provoking new ideas. … The audience includes clinicians and scientists interested in the fetal origin of disease. … this is an interesting book about a worthwhile topic in obstetrics. … it is a worthwhile contribution to the field.” (Anthony Shanks, Doody’s Review Service, December, 2010)

Editors and Affiliations

  • Kennedy Krieger Institute, Center for Autism and Related Disorders, Johns Hopkins University, Baltimore, USA

    Andrew W. Zimmerman

  • Massachusetts General Hospital for Child, Lurie Family Autism Center / LADDERS Cli, Lexington, USA

    Susan L. Connors

Bibliographic Information

  • Book Title: Maternal Influences on Fetal Neurodevelopment

  • Book Subtitle: Clinical and Research Aspects

  • Editors: Andrew W. Zimmerman, Susan L. Connors

  • DOI: https://doi.org/10.1007/978-1-60327-921-5

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2010

  • Hardcover ISBN: 978-1-60327-920-8Published: 10 September 2010

  • Softcover ISBN: 978-1-4899-8161-5Published: 20 October 2014

  • eBook ISBN: 978-1-60327-921-5Published: 08 September 2010

  • Edition Number: 1

  • Number of Pages: XII, 166

  • Topics: Neurology, Obstetrics/Perinatology/Midwifery, Gynecology, Human Physiology, Neurosciences, Human Genetics

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