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Guide to Signal Pathways in Immune Cells

  • Book
  • © 2009

Overview

Authors:
  1. E. Nigel Wardle
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  • An up-to-date guide, which reduces the need for extensive library or computer research in the field of Signal Transduction in Immune Defense Cells
  • One among very few titles that focus on Signal Transduction

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. Cellular Activation Processes

    • E. Nigel Wardle
    Pages 1-10

  3. Cell Membrane Receptors and Phospholipids

    • E. Nigel Wardle
    Pages 11-23

  4. Platelet Aggregation and Its Control

    • E. Nigel Wardle
    Pages 25-35

  5. Introduction to Signalling Cascades

    • E. Nigel Wardle
    Pages 37-75

  6. Cell Proliferation

    • E. Nigel Wardle
    Pages 77-90

  7. Mast Cell Activation and the Role of Eicosanoids

    • E. Nigel Wardle
    Pages 91-99

  8. Lipid Products and Cell Signaling

    • E. Nigel Wardle
    Pages 101-109

  9. Programmed Cell Death: Apoptosis

    • E. Nigel Wardle
    Pages 111-128

  10. Control of the Cytoskeleton

    • E. Nigel Wardle
    Pages 129-151

  11. Leucocyte Activation and Behaviour

    • E. Nigel Wardle
    Pages 153-173

  12. Cell Defence and Survival

    • E. Nigel Wardle
    Pages 175-199

  13. Signalling in Immune Reactions

    • E. Nigel Wardle
    Pages 201-246

  14. T Lymphocytes

    • E. Nigel Wardle
    Pages 247-292

  15. Immunological Controls

    • E. Nigel Wardle
    Pages 293-322

  16. Natural Killer Cells

    • E. Nigel Wardle
    Pages 323-335

  17. B Lymphocytes

    • E. Nigel Wardle
    Pages 337-353

  18. The Cell Cycle

    • E. Nigel Wardle
    Pages 355-372

  19. Cancer

    • E. Nigel Wardle
    Pages 373-403

  20. Back Matter

    Pages 405-415
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Keywords

About this book

To read current biomedical science, one has to have a working knowledge of how important effector molecules cause transduction of their signal within cells, altering the control of genes. This work aims to provide that basic knowledge for medical readers. Students of immunology or cell biology will note its relevance. One will learn how platelets, macrophages, neutrophils, T and B lymphocytes and natural killer cells perform their functions and how skin, breast, prostate and colon cancers emerge. The associated diagrams and tables are used to obviate extensive text. Appropriate references to articles and reviews by workers in each field are given so that further consideration can easily be undertaken. We are all at differing stages of our appreciation of immunology and of pat- physiology. Some persons will have a profound background in biochemistry or molecular biology. Others will have a reminiscence of lectures received years ago. Since this work is principally for clinical doctors, the sections that can be avoided at first reading are marked with an asterisk (*). Always proceed line by line and think of associations that you know. Do you feel comfortable with the statement, “Interleukin 6 stimulates glucose uptake in renal proximal tubular cells, and that action is associated with Stat3, PI3K/Akt, MAPKs and NF-kB signal pathways”? If not, please read on.

Reviews

From the reviews:

“This book describes the basic signaling pathways that are used by cells of the immune system … . The target audience is students, particularly those interested in immune mechanisms. Another group that may find it useful includes physicians who have not kept up with the signal transduction pathway literature and need updated information. … It would certainly be useful for clinicians who have not kept up to date on these pathways and do not have the time to search for review articles.” (Marion C. Cohen, Doody’s Review Service, December, 2009)

“I found this to be a remarkable book. The scope of the volume is very wide, covering both the generalities and specifics of cell signalling in the immune system. … General areas … are succinctly covered with informative tables and appropriate line drawings. … An excellent book which one would be happy to find in the library … .” (Eric Blair, Microbiology Today, January, 2010)

Bibliographic Information

  • Book Title: Guide to Signal Pathways in Immune Cells

  • Authors: E. Nigel Wardle

  • DOI: https://doi.org/10.1007/978-1-60327-538-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2009

  • Hardcover ISBN: 978-1-60327-537-8Published: 28 April 2009

  • Softcover ISBN: 978-1-61737-907-9Published: 05 November 2010

  • eBook ISBN: 978-1-60327-538-5Published: 21 April 2009

  • Edition Number: 1

  • Number of Pages: XXII, 415

  • Number of Illustrations: 141 b/w illustrations

  • Topics: Immunology, Cell Biology, Biochemistry, general

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