Cushing's Syndrome

1. Front Matter

   Pages i-xi

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2. Physiology and Pathophysiology of the HPA Axis

   • Margaret Castro, Lucila Leico Elias, Paula Conde Lamparelli Elias, Ayrton Custodio Moreira

   Pages 1-20

3. Etiologies of Cushing’s Syndrome

   • John Newell-Price

   Pages 21-29

4. Pathogenesis of Corticotropic Tumors

   • Anat Ben-Shlomo, Ning-Ai Liu, Shlomo Melmed

   Pages 31-40

5. Pathogenesis of Adrenocortical Tumors

   • Madson Q. Almeida, Emilia M. Pinto, Ana Claudia Latronico

   Pages 41-52

6. Clinical Features of Cushing’s Syndrome

   • Oscar D. Bruno

   Pages 53-64

7. Laboratorial Diagnosis of Cushing’s Syndrome: Differential Diagnosis with Pseudo Cushing’s Conditions as Obesity, Alcoholism and Depression

   • Martina De Martin, Francesca Pecori Giraldi, Francesco Cavagnini

   Pages 65-78

8. Laboratorial Diagnosis of Cushing’s Syndrome: Differential Diagnosis Among the Different Causes of ACTH-Dependent and ACTH-Independent Cushing’s Syndrome

   • Antonio M. Lerário, Marcello D. Bronstein

   Pages 79-89

9. Imaging for the Differential Diagnosis of Cushing’s Syndrome: MRI, CT, and Isotopic Scanning

   • Wouter W. de Herder, Richard A. Feelders

   Pages 91-103

10. Inferior Petrosal Sampling for the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome

    • Bradley R. Javorsky, James W. Findling

    Pages 105-119

11. The Surgical Management of Cushing’s Disease

    • Ian F. Dunn, Edward R. Laws Jr

    Pages 121-129

12. Adrenal-Directed Treatment Options for Cushing’s Disease

    • William F. Young Jr., Geoffrey B. Thompson

    Pages 131-137

13. Radiation Therapy and Stereotactic Radiosurgery for Cushing’s Disease

    • Jay Jagannathan, Edward R. Laws, Jason P. Sheehan

    Pages 139-149

14. Medical Management of Cushing’s Syndrome

    • Cuong Dang, Peter J. Trainer

    Pages 151-162

15. ACTH-Dependent Cushing Syndrome: Clinical and Diagnostic Aspects, and Treatment Approaches for Ectopic Cushing’s Syndrome

    • Krystallenia I. Alexandraki, Andrea M. Isidori, Ashley B. Grossman

    Pages 163-176

16. Revisiting the Nelson’s Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing’s Disease

    • Guillaume Assie, Laurence Guignat, Jérôme Bertherat, Xavier Bertagna

    Pages 177-187

17. ACTH-Independent Cushing’s Syndrome: Adrenocortical Tumors

    • Maria Candida Barisson Villares Fragoso, Sorahia Domenice, Ana Claudia Latronico, Berenice Bilharinho Mendonca

    Pages 189-208

18. ACTH-Independent Cushing’s Syndrome: Bilateral Macronodular Hyperplasia

    • Isabelle Bourdeau, Antoine Lampron, Tânia Longo Mazzuco, André Lacroix

    Pages 209-224

19. ACTH-Independent Cushing’s Syndrome: Primary Pigmented Nodular Adrenal Disease in the Context of Carney’s Complex

    • Constantine Stratakis

    Pages 225-234

20. Glucocorticoid Resistance

    • Elisabeth F. C. van Rossum, Steven W. J. Lamberts

    Pages 235-248

Cushing´s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing’s syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing´s syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.

• Endocrinology

From the reviews:

“This book contains 23 chapters written by 56 carefully selected experts from three continents. There are special chapters on physiology and pathophysiology of hypothalamic-pituitary-adrenal system as well as on the etiology of Cushing’s syndrome. … Several chapters deal in detail with surgical management, adrenal directed treatment, radiation therapy and medical management. … this book gives outstanding knowledge and is enriching the contemporaneous status of art on Cushing’s syndrome.” (Endocrine Regulations, January, 2012)

“Part of the Contemporary Endocrinology series, a very comprehensive treatise on this difficult to diagnose and treat to disease. Written by multidisciplinary scientists from several countries, it reviews in 23 chapters the physiology and pathophysiology of the HPA axis, the etiology and clinical features of Cushing’s syndrome (CS), diagnostic methods and problems, the various methods of treatment and differential diagnosis including ACTH independent CS. … Clearly written and highly illustrated … . Recommended.” (Pediatric Endocrinology Reviews (PER), Vol. 9 (2), December, 2011)

• , Division of Endocrinology and Metabolism, Hospital das Clínicas, University of Sao, Sao Paulo, Brazil

  Marcello D. Bronstein

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