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Metal Carcinogenesis Testing

Principles and In Vitro Methods

  • Book
  • © 1980

Overview

Authors:
  1. Max Costa

    1. University of Texas Medical School at Houston

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Part of the book series: Biological Methods (BM)

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Table of contents (8 protocols)

  1. Front Matter

    Pages i-xiii
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  2. Metal-Induced Cancer in Humans and Experimental Animals

    1. Front Matter

      Pages 1-1
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    2. Epidemiological Studies and Occupational Exposures

      • Max Costa
      Pages 3-24

    3. Metal Carcinogenesis In Experimental Animals

      • Max Costa
      Pages 25-40

    4. Exposure to Metal Carcinogens In The General Population

      • Max Costa
      Pages 41-56

  3. Mechanisms of Metal Carcinogenesis

    1. Front Matter

      Pages 57-57
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    2. Molecular Mechanisms of Metal Carcinogenesis in Experimental Animals

      • Max Costa
      Pages 59-66

    3. In Vitro and Cell Culture Analysis of Metal Carcinogenesis

      • Max Costa
      Pages 67-85

  4. Principles and Methods of In Vitro Metal Carcinogensis Testing

    1. Front Matter

      Pages 87-87
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    2. Principles of In Vitro Metal Carcinogenesis

      • Max Costa
      Pages 89-116

    3. Methods for In Vitro Metal Carcinogenesis Testing

      • Max Costa
      Pages 117-148

    4. Principles and Methods of Industrial Metal Carcinogenesis Testing

      • Max Costa
      Pages 149-164

  5. Back Matter

    Pages 1-4
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Keywords

About this book

Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci­ nogenic metals and their compounds. Mounting experimental evidence has suggested that a number of metals and their compounds are potentially carcinogenic to humans. Since humans are exposed to these potentially carcinogenic metals in industrial situations and through environmental pollution, it is essential that experimental protocols be available to identify the specific metal compounds that are potentially carcinogenic. This book affords a thorough description of the various carcinogenesis test systems available for metals, centering on those that are rapid, inexpensive, and most reliable. The principles are discussed at the level of human exposure, of animal studies, and of research in vitro. Additionally, the molecular mechanisms of metal-induced cancer are considered at each ofthese three levels.In large part, the emphasis rests on the use of in vitro, biochemical and bacterial studies, including tissue culture, because these methods are the basis of the rapid and inexpensive screening of potentially carcinogenic substances.

Authors and Affiliations

  • University of Texas Medical School at Houston

    Max Costa

Bibliographic Information

  • Book Title: Metal Carcinogenesis Testing

  • Book Subtitle: Principles and In Vitro Methods

  • Authors: Max Costa

  • Series Title: Biological Methods

  • DOI: https://doi.org/10.1007/978-1-60327-403-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media LLC 1980

  • Hardcover ISBN: 978-0-89603-017-6Published: 30 November 1980

  • Softcover ISBN: 978-1-4899-4091-9Published: 09 December 2013

  • eBook ISBN: 978-1-60327-403-6Published: 07 February 2008

  • Edition Number: 1

  • Number of Pages: XIII, 169

  • Topics: Pathology, Pharmacology/Toxicology, Cancer Research

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