Hematopoietic Stem Cell Biology

1. Front Matter

   Pages 1-11

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2. Principles of Hematopoietic Stem Cell Biology

   • Hideo Ema, Toshihiro Kobayashi, Hiromitsu Nakauchi

   Pages 1-36

3. Hematopoietic Stem Cells and Their Niche

   • Hiroko Iwasaki, Toshio Suda

   Pages 37-55

4. Hematopoietic Stem Cells and Somatic Stem Cells

   • Kah Yong Tan, Francis S. Kim, Amy J. Wagers, Shane R. Mayack

   Pages 57-92

5. Developmental Biology of Mammalian T-Cell Progenitors: From Early Lymphoid Progenitors to Thymus-Colonizing Cells

   • Sophie Ezine, Laetitia Gautreau, Aude Parcelier, Bruno Canque

   Pages 93-116

6. GATA1 and GATA2 Function in Hematopoietic Differentiation

   • Takashi Moriguchi, Mikiko Suzuki, James Douglas Engel, Masayuki Yamamoto

   Pages 117-142

7. Role of the IL-7 Receptor in γδ T-Cell Development from Hematopoietic Stem Cells

   • Koichi Ikuta, Shizue Tani-ichi

   Pages 143-159

8. Dendritic Cell Homeostasis: Physiology and Impact on Disease

   • Miriam Merad, Markus G. Manz

   Pages 161-212

9. Wnt in Hematopoietic and Leukemic Stem Cells

   • Kim-Hien T. Dao, H. M. Jamieson Catriona

   Pages 213-243

10. Back Matter

    Pages 1-7

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In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine.

• Thymus
• cell biology
• developmental biology
• physiology
• regulation

From the reviews:

“The text is exceptionally well written by 23 contributors from Japan, the United States, France, and Switzerland­­–– all experts in their respective fields of hematopoietic stem cell biology and lymphocyte physiology. … Hematopoietic Stem Cell Biology will be most helpful and interesting to readers wanting a current update of the field. It is well indexed and well referenced, although it includes few figures, schemas, or photographs to help elucidate the text.” (Paulette Mehta, Journal of the American Medical Association, Vol. 304 (18), November, 2010)

• Duke University Medical Center, Durham, USA

  Motonari Kondo

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