Overview
- Editors:
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Sigrid C. Veasey
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Table of contents (12 chapters)
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Front Matter
Pages i-xiii
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- Kenneth T. Kishida, Eric Klann
Pages 1-27
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- Alba Rossi-George, Andrew Gow
Pages 29-44
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- Gábor Bánhegyi, Éva Margittai, Miklós Csala, József Mandl
Pages 45-64
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- Mark P. Zanin, Damien J. Keating
Pages 65-81
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- Eitan Okun, Mark P. Mattson
Pages 83-95
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- Rosemary H. Milton, Andrey Y. Abramov
Pages 97-108
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- Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Hyoung-Gon Lee, Gjumrakch Aliev, Mark A. Smith et al.
Pages 109-120
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- Robert B. Petersen, Akihiko Nunomura, Hyoung-gon Lee, Gemma Casadesus, George Perry, Mark A. Smith et al.
Pages 121-136
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- Rukhsana Sultana, Renã A. Sowell, D. Allan Butterfield
Pages 137-157
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- Pratap Chand, Irene Litvan
Pages 159-178
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- Alison I. Bernstein, Karen L. O’Malley
Pages 179-192
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- Ramez Wassef, Stefan H. Heinemann, Toshinori Hoshi
Pages 193-206
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Back Matter
Pages 207-215
About this book
Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation [1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes [2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer’s disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and lifespan [4–6]. Today, his research and mentorship have positively influenced the work of hundreds of scientists in this field. We dedicate this book to Dr. Earl R. Stadtman (1912–2008), in celebration of his passion for science and his superior collaborative and mentorship skills. This book is comprised of three sections. The first describes the valuable roles reactive oxygen species (ROS) and reactive nitrogen species (RNS) play in cellular biology. The second section provides an overview of redox imbalance injury with effects on mitochondria, signaling, endoplasmic reticular function, and on aging in general. The third section takes these mechanisms to neurodegenerative disorders and provides a state-of-the-art look at the roles redox imbalances play in age-related susceptibility to disease and in the disease processes. In the first section we attempt to answer a question posed by Dr. Stadtman, ‘‘Why have cells selected reactive oxygen species to regulate cell signaling events’’ [7].
Reviews
From the reviews:
“This book addresses how oxidative stress contributes to age-related cellular dysfunction particularly in Alzheimer's ischemia, Parkinson's disease, and other neurodegenerative conditions. The book fills a niche, addressing the current molecular understanding of oxidative stress and its role in pathophysiology. … it is most appropriate for the many neuroscientists around the world contemplating how to identify the next best approach for targeted therapy for several neurodegenerative diseases. … the book is a good resource for libraries with PhD graduate students and molecular neuroscience laboratories.” (Joseph I. Sirven, Doody’s Review Service, December, 2009)
