Overview
- Presents a framework of basic and clinical studies aimed at developing improved analgesic drugs
- Contains detailed protocols for studying both ion channels and G protein-linked receptors as targets for analgesics
- Delves into subjects as diverse as alternatives to animal pain models (e.g. C. elegans and Drosophila), photoaffinity labeling of volatile analgesic drugs, standardization of pain measurements in clinical trials, congenital insensitivity to pain, and personalized medicine
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 617)
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Table of contents (39 protocols)
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Front Matter
Keywords
About this book
Chronic pain is a complex phenomenon, which continues to remain undertreated in the majority of affected patients thus representing a significant unmet medical need, but the development of cellular, subcellular, and molecular methods of approaching this epidemic of pain shows great promise. In Analgesia: Methods and Protocols, experts in the field present thorough coverage of molecular analgesia research methods from target discovery through target validation and clinical testing to tolerance and dependence, with extensive chapters on emerging receptor classes as targets for analgesic drugs and innovative analgesic strategies. As a volume in the highly successful Methods in Molecular Biology™ series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes sections with tips on troubleshooting and avoiding known pitfalls.
Comprehensive and essential, Analgesia: Methods and Protocols promises to aid and enrich the research of all those scientists and clinicians who are interested in what the increasingly molecular future has in store for analgesia research, from the molecular research bench through the animal laboratory to the bedside.
Reviews
From the reviews:
“The text provides all one wishes to know about research methods in analgesia. … editor’s decision to invite groups of authors and experts from the different areas of research in analgesia, has allowed a broad and up-to-date view of the field. … This book is of great value for investigators, students and physicians interested in understanding pain and the mechanisms involved in its relief. On consulting this book, researchers, students and professionals will have the opportunity to update their knowledge of experimental methods in analgesia.” (Zuleica Bruno Fortes, Brazilian Journal of Pharmaceutical Sciences, Vol. 46 (4), October-December, 2010)
“This book is a collection of methods used to study pain physiology, pharmacology, and genetics described by researchers in the field. … intended to assist basic scientists and clinicians who are interested in the molecular aspects of pain research. … This is a most unique book in the field of pain medicine. … The book imparts a lot of information about the future of pain medicine and is a must read for pain physicians who want to be at their best when managing their patients.” (Tariq M. Malik, Doody’s Book Reviews, August, 2010)Editors and Affiliations
Bibliographic Information
Book Title: Analgesia
Book Subtitle: Methods and Protocols
Editors: Arpad Szallasi
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-60327-323-7
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC 2010
Hardcover ISBN: 978-1-60327-322-0Published: 25 March 2010
Softcover ISBN: 978-1-4939-5699-9Published: 23 August 2016
eBook ISBN: 978-1-60327-323-7Published: 25 March 2010
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XVII, 560
Topics: Pharmacology/Toxicology, Pain Medicine, Pharmacy