Overview
- Editors:
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Vinagolu K. Rajasekhar
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Memorial Sloan-Kettering Cancer Center, New York, USA
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Mohan C. Vemuri
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Invitrogen Corporation, Frederick, USA
- Incorporates all essential and relevant information in the study of stem cells
- Excellently presented data by leading experts in the field of stem cells
- Includes supplementary material: sn.pub/extras
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Table of contents (43 chapters)
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Molecular Regulation in Stem Cells
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- Leon M. Ptaszek, Chad A. Cowan
Pages 27-36
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- Atsushi Suzuki, Ángel Raya, Yasuhiko Kawakami, Masanobu Morita, Takaaki Matsui, Kinichi Nakashima et al.
Pages 37-53
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- Nina J. Kossack, Joerg Gromoll, Renee A. Reijo Pera
Pages 55-66
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- Irene Riz, Robert G. Hawley
Pages 67-74
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- Dimitris G. Placantonakis, Mark J. Tomishima, Fabien G. Lafaille, Lorenz Studer
Pages 75-86
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- Emily Walker, William L. Stanford
Pages 87-100
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- Colleen E. Albacker, Leonard I. Zon
Pages 101-110
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- Eiso Hiyama, Keiko Hiyama
Pages 123-134
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- Claudia Nesti, Livia Pasquali, Michelangelo Mancuso, Gabriele Siciliano
Pages 137-143
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Regulation by Stem Cell Niches
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Front Matter
Pages 145-145
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- Hiroko Iwasaki, Toshio Suda
Pages 165-173
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- Meirav Pevsner-Fischer, Dov Zipori
Pages 175-184
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- Thomas P. Lozito, Catherine M. Kolf, Rocky S. Tuan
Pages 185-210
About this book
Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals ofdevelopmental biology.
Reviews
From the reviews:
“This volume is an initial attempt to decipher the key factors involved in stem cell pluripotency, maintenance, and directed differentiation toward specific cell lineages and stem cell types. The presentation of the contents is such that upper-grade undergraduates, graduate students, postgraduates, and basic research as well as clinical research scientists are provided with accessible information about recent advances in the stem cell field. The volume consists of 43 comprehensively written chapters divided into five parts … .” (Anticancer Research, Vol. 29 (11), November, 2009)
Editors and Affiliations
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Memorial Sloan-Kettering Cancer Center, New York, USA
Vinagolu K. Rajasekhar
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Invitrogen Corporation, Frederick, USA
Mohan C. Vemuri
