Editors:
- Provides an easily accessible reference volume for microarray-based analyses of the physical genome, written by leading researchers in the field
- Covers a wide range of microarray platforms and applications
- Details microarray approaches, "wet-bench" methods, and computational analyses
- Provides easy to follow microarray protocols, with tips and expert commentary
- Comprehensive guide to designing, running and analyzing microarray-based studies of the physical genome
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 556)
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Table of contents (15 protocols)
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Front Matter
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Back Matter
About this book
In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine methylation, protein binding sites, regulatory elements, and replication timing, with an emphasis on higher eukaryote (animal) and cancer genomes. Written in the highly successful Methods in Molecular Biology™ series format, chapters include a brief introduction to their respective subjects, lists of the necessary materials and reagents, step-by-step protocols, and time-saving notes on troubleshooting and avoiding known pitfalls.
Authoritative and easy-to-use, Microarray Analysis of the Physical Genome: Methods and Protocols is of great value to the molecular biologist or computational biologist interested in understanding the principles of these analyses or in planning future experiments using microarrays to characterize the physical genome.
Bibliographic Information
Book Title: Microarray Analysis of the Physical Genome
Book Subtitle: Methods and Protocols
Editors: Jonathan R. Pollack
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-60327-192-9
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2009
Hardcover ISBN: 978-1-60327-191-2Published: 21 July 2009
Softcover ISBN: 978-1-61779-490-2Published: 06 December 2011
eBook ISBN: 978-1-60327-192-9Published: 02 June 2009
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: X, 224
Number of Illustrations: 36 b/w illustrations
Topics: Biochemistry, general, Human Genetics, Microarrays