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The Metabolic Syndrome:

Epidemiology, Clinical Treatment, and Underlying Mechanisms

  • Book
  • © 2008

Overview

Editors:
  1. Barbara Caleen Hansen

    1. Obesity, Diabetes, and Aging Research Center, University of South Florida College of Medicine, Tampa

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  2. George A. Bray

    1. Pennington Biomedical Research Center, Louisiana State University, Baton Rouge

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    You can also search for this editor in PubMed   Google Scholar

  • Editors and authors are renowned experts from the basic and clinical sciences
  • Provides state-of-the-art the overview of the metabolic syndrome
  • Details both the basic and clinical science surrounding the syndrome
  • Offers a cross disciplinary analysis on intersecting pathways that play a role in the metabolic syndrome
  • Includes supplementary material: sn.pub/extras

Part of the book series: Contemporary Endocrinology (COE)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xii
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  2. Metabolic Syndrome—Past and Future

    1. Metabolic Syndrome—Past and Future

      • Barbara Caleen Hansen, Rosemary Peternel, George A. Bray
      Pages 1-7

  3. Epidemilogy And Clinical Treatment: Issues In Defining And Treating The Metabolic Syndrome

    1. Front Matter

      Pages 9-9
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    2. Metabolic Syndrome

      • Gerald M. Reaven
      Pages 11-36

    3. The Role of Obesity in Insulin Resistance

      • James B. Meigs
      Pages 37-55

    4. Treatment of the Metabolic Syndrome with Weight Loss, Exercise, Hormones, and Surgery

      • George A. Bray
      Pages 57-73

    5. Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease

      • Earl S. Ford, Simin Liu
      Pages 75-84

    6. The Sympatho-Adrenal System in the Metabolic Syndrome

      • Lewis Landsberg
      Pages 85-104

  4. Endothelial Function, Inflammation, and Dyslipidemia

    1. Front Matter

      Pages 105-105
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    2. Insulin Action and Endothelial Function

      • Kieren J. Mather, Alain Baron, Michael J. Quon
      Pages 107-135

    3. Macro- and Microvascular Disease in an Insulin-Resistant Pre-Diabetic Animal Model

      • James C. Russell, Spencer D. Proctor
      Pages 137-166

    4. High-Sensitivity C-Reactive Protein and the Metabolic Syndrome

      • Yiqing Song, Simin Liu, Joann E. Manson
      Pages 167-188

    5. Insulin Signaling in Adipocytes and the Role of Inflammation

      • Christian X. Andersson, Ann Hammarstedt, Per-Anders Jansson, Ulf Smith
      Pages 189-204

    6. Insulin Resistance and Dyslipidemia

      • Tina J. Chahil, Gissette Reyes, Henry N. Ginsberg
      Pages 205-218

  5. Insulin—Secretion and Action: Underlying Mechanisms of the Metabolic Syndrome

    1. Front Matter

      Pages 219-219
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    2. Pancreatic Islet Pathophysiology and Pathology in Obesity

      • Anne Clark, Jenni Moffitt, Lianne Van De Laar, Katherine Pinnick, Farhina Sayyed
      Pages 221-232

    3. Glucagon-like Peptides and Insulin Sensitivity

      • Jens Juul Holst, Filip Krag Knop
      Pages 233-254

    4. The Relationship Between the Insulin Receptor Substrates and Metabolic Disease

      • Morris F. White
      Pages 255-278

    5. Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase

      • Jack F. Youngren
      Pages 279-305

    6. Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance

      • E. W. Kraegen, G. J. Cooney, Jiming M. Ye, Stuart M. Furler
      Pages 307-328
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Keywords

About this book

In the United States, 40 to 45% of those over 60 years of age have the metabolic syndrome (1,2,3), and this percentage, based on estimates of the increasing prevalence ofexcess body weight and the more comprehensive diagnostic criteria for the syndrome, is likely to exceed 60% in newer survey analyses. Children and adolescents, too, are being affected by the metabolic syndrome, in parallel with the increasing prevalence of overweight in young people, now estimated to include 16% of those age 6 to 19 years. Clinicians see with increasing frequency that routine office visits demonstrate the meta­ bolic syndrome, a constellation of discrete but closely related metabolic disturbances indicative of increased risk for (or presence of) cardiovascular disease and/or diabetes. All estimates suggest the increasing impactof the metabolic syndrome on mortality and morbidity (4). Our aim in developing this new synthesis and analysis of the metabolic syndrome has been to bring together the viewpoints of the epidemiologists, the physiologists, the molecular biologists/biochemists, and the clinicians toward understanding the current state ofknowledge ofboth the causes and the consequences of the metabolic syndrome. These writers aim to stimulate new thinking concerning underlying mechanisms and to encourage heightened efforts to develop new therapeutics, potentially targeting uniquely intersecting pathways or points of intervention. This book is an extended call to action to slow or halt the rising tide of the metabolic syndrome (5).

Reviews

From the reviews:

"This book presents a balanced view of the controversies surrounding the metabolic syndrome and supplies the reader with a detailed account of the key issues that divide the various camps. … is an admirable collection of scientifically focused and up-to-date views of the current thinking on the metabolic syndrome. It can be recommended for scientists working in this field as well as for clinicians who wish to gain a deeper understanding of this complex syndrome." (Arne Astrup, The New England Journal of Medicine, July, 2008)

"This book covers three major perspective of the metabolic syndrome … . this book is written for an endocrinology audience and anyone who has a strong interest in the link between the basic science of insulin resistance and the clinical manifestations of the metabolic syndrome. Practitioners will find useful information about the underlying mechanisms of the disease as well as an overview of treatment approaches. … This is a high quality review of insulin resistance targeted at endocrinologists and basic scientists." (Matthew J. Sorrentino, Doody’s Review Service, November, 2008)

Editors and Affiliations

  • Obesity, Diabetes, and Aging Research Center, University of South Florida College of Medicine, Tampa

    Barbara Caleen Hansen

  • Pennington Biomedical Research Center, Louisiana State University, Baton Rouge

    George A. Bray

Bibliographic Information

  • Book Title: The Metabolic Syndrome:

  • Book Subtitle: Epidemiology, Clinical Treatment, and Underlying Mechanisms

  • Editors: Barbara Caleen Hansen, George A. Bray

  • Series Title: Contemporary Endocrinology

  • DOI: https://doi.org/10.1007/978-1-60327-116-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-738-9Published: 18 January 2008

  • Softcover ISBN: 978-1-61737-750-1Published: 09 November 2010

  • eBook ISBN: 978-1-60327-116-5Published: 06 May 2010

  • Series ISSN: 2523-3785

  • Series E-ISSN: 2523-3793

  • Edition Number: 1

  • Number of Pages: XII, 402

  • Topics: Endocrinology, Diabetes, Internal Medicine, Cardiology

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