Skip to main content
SpringerLink
Log in
Book cover

Introduction to Systems Biology

  • Book
  • © 2007

Overview

Editors:
  1. Sangdun Choi

    1. Department of Biological Sciences, Ajou University, Suwon, Korea

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Basic explanation of how to use computational methods to explain underlying biological meanings
  • Introduction into state-of-the-art systems biology
  • Contains typical approaches to experimental design, both wet-lab and computational
  • Includes supplementary material: sn.pub/extras

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (25 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Scientific Challenges in Systems Biology

      • Hiroaki Kitano
      Pages 3-13

    3. Bringing Genomes to Life: The Use of Genome-Scale In Silico Models

      • Ines Thiele, Bernhard Ø. Palsson
      Pages 14-36

    4. From Gene Expression to Metabolic Fluxes

      • Ana Paula Oliveira, Michael C. Jewett, Jens Nielsen
      Pages 37-66

  3. Experimental Techniques for Systems Biology

    1. Front Matter

      Pages 67-67
      Download chapter PDF

    2. Handling and Interpreting Gene Groups

      • Nils Blüthgen, Szymon M. Kielbasa, Dieter Beule
      Pages 69-84

    3. The Dynamic Transcriptome of Mice

      • Yuki Hasegawa, Yoshihide Hayashizaki
      Pages 85-105

    4. Dissecting Transcriptional Control Networks

      • Vijayalakshmi H. Nagaraj, Anirvan M. Sengupta
      Pages 106-123

    5. Reconstruction and Structural Analysis of Metabolic and Regulatory Networks

      • Hong-wu Ma, Marcio Rosa da Silva, Ji-Bin Sun, Bharani Kumar, An-Ping Zeng
      Pages 124-146

    6. Cross-Species Comparison Using Expression Data

      • Gaëlle Lelandais, Stéphane Le Crom
      Pages 147-159

    7. Methods for Protein-Protein Interaction Analysis

      • Keiji Kito, Takashi Ito
      Pages 160-182

    8. Genome-Scale Assessment of Phenotypic Changes During Adaptive Evolution

      • Stephen S. Fong
      Pages 183-195

    9. Location Proteomics

      • Ting Zhao, Shann-Ching Chen, Robert F. Murphy
      Pages 196-214

  4. Theoretical and Modeling Techniques

    1. Front Matter

      Pages 215-215
      Download chapter PDF

    2. Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models

      • Matthew J. Beal, Juan Li, Zoubin Ghahramani, David L. Wild
      Pages 217-241

    3. Modeling Spatiotemporal Dynamics of Multicellular Signaling

      • Hao Zhu, Pawan K. Dhar
      Pages 242-260

    4. Kinetics of Dimension-Restricted Conditions

      • Noriko Hiroi, Akira Funahashi
      Pages 261-281

    5. Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction

      • Nils Blüthgen, Stefan Legewie, Hanspeter Herzel, Boris Kholodenko
      Pages 282-299

    6. Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space

      • Boris N. Kholodenko
      Pages 300-318
Back to top

Keywords

About this book

Introduction to Systems Biology is an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors provide a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches to help understand biological dynamic systems. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.

Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.

Editors and Affiliations

  • Department of Biological Sciences, Ajou University, Suwon, Korea

    Sangdun Choi

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation