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Inflammation and Cancer

Methods and Protocols: Volume 1, Experimental Models and Practical Approaches

  • Book
  • © 2009

Overview

Editors:
  1. Serguei V. Kozlov

    1. National Cancer Institute at Frederick, SAIC-Frederick, Inc., Frederick, USA

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  • Contains key readily reproducible experimental approaches certain to be useful as technologies continue to develop
  • Details basic requirements for the most recent techniques still awaiting experimental substantiation
  • Fosters rigorous scientific interactions among basic and clinical researchers aimed at further molecular demarcation of the elaborate pathways leading from inflammation to tumor formation
  • Compiles contemporary laboratory techniques with an emphasis on carcinogenic events mediated by chronic inflammation and pathogen infection
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 511)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Experimental Approaches to Study Chronic Inflammation – Related Carcinogenesis

    1. Collection and Preparation of Rodent Tissue Samples for Histopathological and Molecular Studies in Carcinogenesis

      • Yelena Golubeva, Keith Rogers
      Pages 3-60

    2. Biomarkers of Cell Proliferation in Carcinomas: Detection of Angiogenesis and Infiltrated Leukocytes

      • Coen I. M. Baeten
      Pages 61-73

    3. Assessment of Local Proteolytic Milieu as a Factor in Tumor Invasiveness and Metastasis Formation: In Vitro Collagen Degradation and Invasion Assays

      • Brenda L. Petrella
      Pages 75-84

    4. Cytokine Multiplex Analysis

      • Howard A. Young
      Pages 85-105

    5. Approaches to Determine Expression of Inflammatory Cytokines

      • Derk Amsen, Karin E. de Visser, Terrence Town
      Pages 107-142

    6. Selective Immortalization of Tumor-Specific T Cells to Establish Long-Term T-Cell Lines Maintaining Primary Cell Characteristics

      • Eugene V. Barsov
      Pages 143-158

    7. YKL-40: A Novel Marker Shared by Chronic Inflammation and Oncogenic Transformation

      • Anne Roslind, Julia S. Johansen
      Pages 159-184

    8. Angiogenesis Links Chronic Inflammation with Cancer

      • Hanako Kobayashi, P. Charles Lin
      Pages 185-191

    9. Inflammatory Bowel Disease: A Model of Chronic Inflammation-Induced Cancer

      • Guang-Yu Yang, Sofia Taboada, Jie Liao
      Pages 193-233

  3. Oncogenic Potential of Inflammation Induced by Viral and Bacterial Infections

    1. Gastric Carcinogenesis and Helicobacter pylori Infection

      • Christine Varon, Jean-François Mosnier, Philippe Lehours, Tamara Matysiak-Budnik, Francis Mégraud
      Pages 237-265

    2. Helicobacter -Based Mouse Models of Digestive System Carcinogenesis

      • Arlin B. Rogers, JeanMarie Houghton
      Pages 267-295

    3. Screening for Molecular Markers of Cervical Papillomavirus Infection: Overview of Methods and Their Clinical Implications

      • Donna Dehn, Adriann Taylor, Timothy J. Fischer, Douglas P. Malinowski, Kenneth R. Shroyer
      Pages 297-310

    4. Screening for Epstein–Barr Virus in Hodgkin's Lymphoma

      • Gulfaraz Khan
      Pages 311-322

    5. A Hepatitis C Virus Xenograft Mouse Efficacy Model

      • Qing Zhu, Amy J. Weiner
      Pages 323-331

    6. Gene Expression Profiling in Cervical Cancer: Identification of Novel Markers for Disease Diagnosis and Therapy

      • Cara M. Martin, Katharine Astbury, Lynda McEvoy, Sharon O'Toole, Orla Sheils, John J. O'Leary
      Pages 333-359

    7. Detection and Genotyping Analysis of Human Papillomavirus Isolates from Liquid-Based Cervical Cytology Specimens

      • Patricia Avissar, Douglas P. Malinowski
      Pages 361-370

  4. Back Matter

    Pages 371-376
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Keywords

About this book

According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 1, Experimental Models and Practical Approaches provides an overview of a spectrum of techniques developed to analyze the outcomes of inflammation-mediated carcinogenesis on the tissue, cellular, and molecular levels while highlighting several diagnostic aspects, such as biomarker discovery and molecular signatures evaluation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.

Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.

Editors and Affiliations

  • National Cancer Institute at Frederick, SAIC-Frederick, Inc., Frederick, USA

    Serguei V. Kozlov

Bibliographic Information

  • Book Title: Inflammation and Cancer

  • Book Subtitle: Methods and Protocols: Volume 1, Experimental Models and Practical Approaches

  • Editors: Serguei V. Kozlov

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-59745-447-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2009

  • Hardcover ISBN: 978-1-934115-14-5Published: 17 April 2009

  • Softcover ISBN: 978-1-61737-923-9Published: 19 November 2010

  • eBook ISBN: 978-1-59745-447-6Published: 05 April 2009

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 378

  • Number of Illustrations: 75 b/w illustrations

  • Topics: Cancer Research, Oncology, Laboratory Medicine

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