Methods in Biobanking

1. Front Matter

   Pages i-xi

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2. Genetic Research and Biobanks

   • Don Chalmers

   Pages 1-37

3. The Need to Downregulate: A Minimal Ethical Framework for Biobank Research

   • Mats G. Hansson

   Pages 39-59

4. Nordic Biological Specimen Bank Cohorts as Basis for Studies of Cancer Causes and Control: Quality Control Tools for Study Cohorts with More than Two Million Sample Donors and 130,000 Prospective Cancers

   • Eero Pukkala

   Pages 61-112

5. Biobanks Collected for Routine Healthcare Purposes: Build-Up and Use for Epidemiologic Research

   • Joakim Dillner, Kristin Andersson

   Pages 113-125

6. Biobanks and Registers in Epidemiologic Research on Cancer

   • Eero Pukkala

   Pages 127-164

7. Study Designs for Biobank-Based Epidemiologic Research on Chronic Diseases

   • Esa Läärä

   Pages 165-178

8. The European Prospective Investigation into Cancer and Nutrition Biobank

   • Pierre Hainaut, Béatrice Vozar, Sabina Rinaldi, Elio Riboli, Elodie Caboux

   Pages 179-191

9. The AIDS and Cancer Specimen Resource

   • Leona W. Ayers, Sylvia Silver, Jan M. Orenstein, Michael S. McGrath, Debra L. Garcia

   Pages 193-203

10. Specific Advantages of Twin Registries and Biobanks

    • Jaakko Kaprio

    Pages 205-213

11. The Swedish Multi-generation Register

    • Anders Ekbom

    Pages 215-220

12. Multigenerational Information: The Example of the Icelandic Genealogy Database

    • Hrafn Tulinius

    Pages 221-229

13. Creation of a New Prospective Research Biobank: The Example of HUNT3

    • Kristian Hveem

    Pages 231-239

14. Best Practices for Establishing a Biobank

    • Göran Hallmans, Jimmie B. Vaught

    Pages 241-260

15. Extraction, Quantitation, and Evaluation of Function DNA from Various Sample Types

    • Malin Ivarsson, Joyce Carlson

    Pages 261-277

16. Cervical Cytology Biobanks as a Resource for Molecular Epidemiology

    • Marc Arbyn, Kristin Andersson, Christine Bergeron, John-Paul Bogers, Magnus von Knebel-Doebertitz, Joakim Dillner

    Pages 279-298

17. Biobanking of Fresh Frozen Tissue from Clinical Surgical Specimens: Transport Logistics, Sample Selection, and Histologic Characterization

    • Johan Botling, Patrick Micke

    Pages 299-306

18. Protein Extraction from Solid Tissue

    • Christer Ericsson, Monica Nistér

    Pages 307-312

19. Collection and Preservation of Frozen Microorganisms

    • Rosamaria Tedeschi, Paolo De Paoli

    Pages 313-326

20. Handling of Solid Brain Tumor Tissue for Protein Analysis

    • Christer Ericsson, Monica Nistér

    Pages 327-332

International biobank collaborations allow for studies with large number of subjects where generalizability of findings across populations can be investigated, which means establishing quality criteria concerning the nature of the sample, conditions of sample storage, and the adequacy of available information is of vital importance. Methods in Biobanking brings together contributions from experts in the field in order to aid in the establishment of this much needed consistency. The volume discusses how to use existing collections of biological material to answer significant questions concerning the cause of disease without violating the personal integrity of participating sample donors, the ethical issues surrounding biobanks, guidelines for the use of coding systems and the use of biocomputing and registry linkages in research projects, as well as many other key subjects. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods in Biobanking seeks to provide scientists with the tools necessary to take advantage of the tremendous current resources of the world’s biobanks and strengthen those resources for the future.

• Biocomputing
• Biological material
• Coding systems
• Epidemiological study design
• Ethical issues
• Population genetics
• Registries

From the reviews:

“The modest aim of Dillner’s tome, to ‘contribute to the development of competence in the subject area of Biobanking’, is admirably met. … As a compendium of interesting topics which are informatively presented by experts in the field the book works. So if you want to dip into the world of biobanking this is the book for you. … it is a useful text for undergraduate or master’s level courses, in which biobanking is a component part.” (John Gallacher, Human Genetics, Vol. 129, 2011)

• , Bio Banking and Molecular Resource, Karolinska Institutet, Stockholm, Sweden

  Joakim Dillner

Policies and ethics