Overview
- Presents full coverage of peptide-based drug development arranged in a sequential order as the leads proceed through the preclinical pipeline
- Describes innovative and unusual technologies
- Special focus on peptide drugs in infectious diseases
- Includes contributions from international leaders in their respective fields
- Provides a balance of scientific rigor, potential reproducibility and drug development economics
Part of the book series: Methods in Molecular Biology (MIMB, volume 494)
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Table of contents (16 protocols)
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Front Matter
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Back Matter
Keywords
About this book
Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biologyâ„¢ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls.
Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.
Editors and Affiliations
Bibliographic Information
Book Title: Peptide-Based Drug Design
Editors: Laszlo Otvos
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-59745-419-3
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2008
Hardcover ISBN: 978-1-58829-990-1Published: 09 October 2008
Softcover ISBN: 978-1-61737-869-0Published: 19 November 2010
eBook ISBN: 978-1-59745-419-3Published: 26 August 2008
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XI, 303