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Molecular Targeting in Oncology

  • Book
  • © 2008

Overview

Editors:
  1. Howard L. Kaufman

    1. Division of Surgical Oncology, Columbia University, New York

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  2. Scott Wadler

    1. Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College Cornell University, NY

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    You can also search for this editor in PubMed   Google Scholar

  3. Karen Antman

    1. Boston University Medical Campus Boston University School of Medicine, Boston

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    You can also search for this editor in PubMed   Google Scholar

  • Five sections cover the most important elements of drug development: Drugs, Strategies, Disease Sites, Classes, and Challenges
  • Sections present different perspectives on how targeted therapeutics are being evaluated

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (31 chapters)

  1. Front Matter

    Pages I-XIV
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  2. General Strategies for Molecular Targeting in Oncology

    1. Front Matter

      Pages 1-1
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    2. The Cell Cycle

      • Chad D. Knights, Richard G. Pestell
      Pages 3-32

    3. mTOR

      • John B. Easton, Peter J. Houghton
      Pages 33-53

    4. Ras/Raf/MEK Inhibitors

      • Joseph A. Sparano
      Pages 55-73

    5. 17-AAG

      • Len Neckers, Percy Ivy
      Pages 75-95

    6. The Cancer Epigenome

      • Sam Thiagalingam, Douglas V. Faller
      Pages 97-113

  3. Molecular Targeting for Specific Disease Sites

    1. Front Matter

      Pages 115-115
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    2. Molecular Targeting in Upper Gastrointestinal Malignancies

      • Scott Wadler
      Pages 117-131

    3. Molecular Targeting of Colorectal Cancer

      • Mark L. Sundermeyer, Alfonso Bellacosa, Neal J. Meropol
      Pages 133-163

    4. Molecular Targeting in Hepatocellular Carcinoma

      • Jonathan D. Schwartz, Josep M. Llovet
      Pages 165-210

    5. Molecularly Targeted Therapy in Pancreatic Cancer

      • Anupama Goel, Peter Kozuch
      Pages 211-226

    6. Untargeted Use of Targeted Therapy

      • Cheryl Ho, Angela M. Davies, Primo N. Lara, O. Gautschi, P.C. Mack, Paul H. Gumerlock et al.
      Pages 227-240

    7. Renal Cell Carcinoma

      • Olwen Hahn, Walter Stadler
      Pages 241-261

    8. Targeted Therapies for Prostate Cancer

      • Elisabeth I. Heath, Michael A. Carducci
      Pages 263-290

    9. Molecular Targets in Ovarian Cancer and Endometrial Cancer

      • Nilofer S. Azad, Gisele Sarosy, Elise C. Kohn
      Pages 291-308

    10. Targeted Therapy For Breast Cancer

      • Deena M. Atieh, Linda T. Vahdat
      Pages 309-342

    11. Melanoma

      • Akshay Gupta, John M. Kirkwood
      Pages 343-367

  4. Classes of Drugs for Molecular Targeting in Oncology

    1. Front Matter

      Pages 369-369
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    2. Antibody Therapy of Cancer

      • Hossein Borghaei, Liat Binyamin, Igor Astsaturov, Louis M. Weiner
      Pages 371-412
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Keywords

About this book

In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more.

Editors and Affiliations

  • Division of Surgical Oncology, Columbia University, New York

    Howard L. Kaufman

  • Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College Cornell University, NY

    Scott Wadler

  • Boston University Medical Campus Boston University School of Medicine, Boston

    Karen Antman

Bibliographic Information

  • Book Title: Molecular Targeting in Oncology

  • Editors: Howard L. Kaufman, Scott Wadler, Karen Antman

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-337-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-577-4Published: 07 January 2008

  • Softcover ISBN: 978-1-61737-653-5Published: 26 May 2011

  • eBook ISBN: 978-1-59745-337-0Published: 26 December 2007

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XVI, 728

  • Topics: Cancer Research, Oncology, Pharmacology/Toxicology, Medicinal Chemistry

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