Stem Cells and Myocardial Regeneration

1. Front Matter

   Pages i-xiii

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2. Economic impact of heart failure

   1. The Challenge for Stem Cell Therapy

      • Marc S. Penn, Eric J. Topol

      Pages 1-6

3. Cells Of Interest For Myocardial Regeneration

   1. Front Matter

      Pages 7-7

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   2. Hematopoietic Stem Cells for Myocardial Regeneration

      • Donald Orlic, Richard O. Cannon III

      Pages 9-28

   3. Mesenchymal Stem Cells for Cardiac Therapy

      • Mark F. Pittenger

      Pages 29-44

   4. Multipotent Adult Progenitor Cells

      • Wouter van’t Hof, Niladri Mal, Amy Raber, Ming Zhang, Anthony Ting, Marc S. et al.

      Pages 45-56

   5. Mesenchymal Progenitor Cells for Vascular Network Formation and Cardiac Muscle Regeneration

      • Silviu Itescu, Fiona See, Timothy Martens

      Pages 57-66

   6. Umbilical Cord Blood Stem Cells for Myocardial Regeneration and Angiogenesis

      • Shyam Bhakta, Mary J. Laughlin

      Pages 67-82

   7. Endogenous Cardiac Stem Cells

      • Elisa Messina, Alessandro Giacomello, Eduardo Marbán

      Pages 83-100

   8. Embryonic Stem Cells for Myocardial Repair

      • Lior Gepstein

      Pages 101-114

4. Mechanisms And Critical Pathways Involved In Myocardial Repair

   1. Front Matter

      Pages 115-115

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   2. Chemokine and Homing Factor Expression in Acute Myocardial Infarction and Chronic Heart Failure

      • Arman T. Askari, Marc S. Penn

      Pages 117-134

   3. Stem Cell Differentiation Toward a Cardiac Myocyte Phenotype

      • Andrea N. Ladd

      Pages 135-150

   4. Electrical Coupling and/or Ventricular Tachycardia Risk of Cell Therapy

      • Dayi Hu, Shuixiang Yang

      Pages 151-158

   5. Cell Therapy for Myocardial Damage

      • William R. Mills, Kenneth R. Laurita

      Pages 159-170

5. Strategies For Cell Delivery: Advantages/Disadvantages

   1. Front Matter

      Pages 171-171

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   2. Aspects of Percutaneous Cellular Cardiomyoplasty

      • Matthew Hook, Patrick Whitlow

      Pages 173-180

   3. Stem Cells and Myocardial Regeneration

      • Roberto Lorusso, Josè L. Navia, Cesare Beghi, Fernando A. Atik

      Pages 181-202

6. Stem Cell-Based Clinical Trials For Cardiac Dysfunction

   1. Front Matter

      Pages 203-203

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   2. Measures of Effective Cell-Based Therapy

      • Jaber Wael A., Cerqueira Manuel D.

      Pages 205-220

Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. With more than 1 million MIs a year in the United States, there are approx 500,000 new cases of CHF diagnosed each year. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.

• angiogenesis
• cardiovascular
• cell
• cell differentiation
• cytokine
• heart
• hematopoietic stem cell
• regeneration
• stem cell
• stem cells
• transplantation
• vascular disease

• Bakken Heart Brain Institute and Coronary Intensive Care Unit, The Cleveland Clinic Foundation Cleveland

  Marc S. Penn

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