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Regulation of Gene Expression

  • Book
  • © 2007

Overview

Editors:
  1. Gary H. Perdew

    1. Center for Molecular Toxicology and Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park

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  2. John P. Heuvel

    1. Center for Molecular Toxicology and Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park

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    You can also search for this editor in PubMed   Google Scholar

  3. Jeffrey M. Peters

    1. Center for Molecular Toxicology and Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-ix
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  2. Gene Expression Control At The Mrna Level

    1. Front Matter

      Pages 1-2
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    2. Overview

      Pages 3-9

    3. Messenger RNA Accumulation

      Pages 11-30

    4. Transcript Profiling

      Pages 31-48

    5. Transcriptional Regulation of Gene Expression

      Pages 49-103

    6. Posttranscriptional Processing of Messenger RNA

      Pages 105-140

  3. Back Matter

    Pages 141-146
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  4. Regulation Of Protein Levels And Transcription Factor Function

    1. Front Matter

      Pages 147-148
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    2. Overview

      Pages 149-153

    3. Protein Synthesis and Turnover

      Pages 155-160

    4. Proteomics

      Pages 161-172

    5. Determination of Protein-Protein Interactions and the Motifs That Mediate Them

      Pages 173-214

    6. Posttranslational Modifications

      Pages 215-238

    7. Dissection of Signaling Pathways

      Pages 239-258

  5. Back Matter

    Pages 259-261
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  6. Use Of Transgenic And Knockout Mice To Study Gene Regulation

    1. Front Matter

      Pages 265-266
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    2. Overview

      Pages 267-269

    3. Production of Transgenic Animals

      Pages 271-293

    4. Knockout Animals

      Pages 295-318
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Keywords

About this book

The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

Reviews

From the reviews:

"The book is aimed at graduate students, filling a gap between more general text books … and laboratory manuals (e.g. the Current Protocols series). … Helpful notes and key references are given in the margins throughout the text. … overall ‘Regulation of Gene Expression: Molecular Mechanisms’ would certainly be of use to life sciences undergraduates, it would also be a useful reference work for a Molecular Toxicology laboratory." (James Sidaway, British Toxicology Society Newsletter, Summer, 2007)

Editors and Affiliations

  • Center for Molecular Toxicology and Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park

    Gary H. Perdew, John P. Heuvel, Jeffrey M. Peters

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