Regional Cancer Therapy

1. Front Matter

   Pages i-xiv

   PDF

2. Background

   1. Front Matter

      Pages 1-1

      PDF

   2. Biological Background

      • Ulrike S. Stein, Wolfgang Walther, Peter M. Schlag

      Pages 3-18

   3. Pharmacological Background

      • Hans Gelderblom, Joost Rothbarth, Cornelius J. H. van de Velde, Henk-Jan Guchelaar

      Pages 19-28

   4. Isolated Limb and Organ Perfusion Laboratory Models

      • Timo L. M. ten Hagen, Alexander M. M. Eggermont

      Pages 29-44

3. Techniques and Prerequisites for Regional Therapy

   1. Front Matter

      Pages 45-45

      PDF

   2. Interventional Radiotherapy

      • Enrique Lopez Hänninen, Timm Denecke

      Pages 47-58

   3. Surgical Strategies

      • Sandra Grünberg, Peter M. Schlag

      Pages 59-72

   4. Regional Thermotherapy

      • Peter Wust, Johanna Gellermann

      Pages 73-90

   5. Radiofrequency Thermal Ablation

      • Eren Berber, Allan E. Siperstein

      Pages 91-100

   6. Cryoablation for Primary and Secondary Liver Tumors

      • Tristan D. Yan, Faruque Riffat, David L. Morris

      Pages 101-115

   7. A Personal History of Photodynamic Therapy

      • Thomas J. Dougherty

      Pages 117-132

   8. Ultrasound-Guided Therapy

      • Robert F. Wong, Amanjit S. Gill, Manoop S. Bhutani

      Pages 133-162

   9. Nanocarriers and Drug Delivery

      • Svetlana Gelperina

      Pages 163-179

   10. Local Gene Therapy for Cancer

       • Wolfgang Walther, Ulrike S. Stein, Peter M. Schlag

       Pages 181-196

4. Indications and Results for Different Tumor Entities

   1. Front Matter

      Pages 197-197

      PDF

   2. Regional Chemotherapy of Primary and Metastatic Liver Tumors

      • Rebecca Taylor, James Tomlinson, Nancy Kemeny

      Pages 199-228

   3. Focal Liver Ablation Techniques in Primary and Secondary Liver Tumors

      • Giuseppe Garcea, David P. Berry

      Pages 229-267

   4. Regional Therapy for Peritoneal Surface Malignancy

      • Yehuda Skornick, Paul H. Sugarbaker

      Pages 269-282

   5. Malignant Peritoneal Mesothelioma

      • David P. Mangiameli, Steven K. Libutti, James F. Pingpank, H. Richard Alexander

      Pages 283-302

Regional cancer therapies remain important options in the management of malignant disease, in spite of the venue of more targeted agents for systemic therapies. New te- nologies and better guidance systems for radiofrequency ablation and intrastitial laser therapies, highly selective intravascular approaches with improved catheters and gu- ance systems, improved agents for embolizations, and new vasoactive drugs for isolated limb and liver perfusions are just a few of the new developments in a field that is alive and progressing. Regional Cancer Therapy, so well put together by the editors Peter M. Schlag and Ulrike S. Stein, presents an overview of today’s realities and tomorrow’s possibilities. Regional cancer therapy models provide ways to make new discoveries about tumor biology and new agents that may be used regionally as well as systemically. This book should therefore be of interest to all clinicians and scientists with an interest in tumor biology as well as clinical advances. Alexander M. M. Eggermont, MD, PhD Professor and Head of Surgical Oncology Erasmus University MC—Daniel den Hoed Cancer Center Rotterdam, the Netherlands v PREFACE The treatment of malignant tumors has been substantially improved in recent years due to developments in clinical medicine and technology as well as by advances in mole- lar biological research. Modern molecular and genetic techniques allow the charact- ization of molecules that are decisive for tumor development and progression.

• Laboratory
• Tumor
• gene therapy
• liver tumor
• positron emission tomography
• ultrasound
• Radiaton Oncology
• surgical oncology

• Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

  Peter M. Schlag

• Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

  Peter M. Schlag, Ulrike Stein

• Tumor Metastasis and Therapy Response Program, Robert-Rössle-Hospital and Tumor Institute, Charité University of Medicine, Berlin

  Ulrike Stein

• Erasmus University MC—Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

  Alexander M. M. Eggermont

Policies and ethics