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Gene Therapy for Cancer

  • Book
  • © 2007

Overview

Editors:
  1. Kelly K. Hunt

    1. The University of Texas M. D. Anderson Cancer Center, Houston

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  2. Stephan A. Vorburger

    1. Inselspital Bern, University of Bern, Bern, Switzerland

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  3. Stephen G. Swisher

    1. The University of Texas M. D. Anderson Cancer Center, Houston

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  • Vectors used in gene therapy for cancer
  • Characteristics and production methods of cancer gene vectors
  • Targets and specific approaches for the therapy of cancer
  • Clinical applications of cancer gene therapy
  • Background knowledge, technical details, and preclinical and clinical results for cancer gene therapy
  • Provides a concise presentation of the current knowledge in cancer gene therapy
  • Will prove incredibly valuable as the volume of preclinical and clinical data continues to increase

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xi
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  2. Vectors

    1. Front Matter

      Pages 1-1
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    2. Adenovector-Mediated Cancer Gene Therapy

      • Bingliang Fang, Jack A. Roth
      Pages 3-22

    3. Efficacy, Toxicity, and Immunogenicity of Adenoviral Vectors

      • Dmitry M. Shayakhmetov
      Pages 23-38

    4. Lentiviral and Retroviral Vector Systems

      • Renata Stripecke, Noriyuki Kasahara
      Pages 39-71

    5. Vaccinia and Pox-Virus

      • Sricharan Chalikonda, David L. Bartlett
      Pages 73-85

    6. Herpes Simplex Virus as a Therapy for Cancer

      • Ian J. Mohr
      Pages 87-108

    7. Alphavirus Vectors for Gene Therapy Applications

      • Kenneth Lundstrom
      Pages 109-119

    8. Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors

      • Glen N. Barber
      Pages 121-140

    9. Parvovirus Vectors

      • Selvarangan Ponnazhagan
      Pages 141-155

    10. Nonviral Vector Systems

      • Pui-yan Lee, Leaf Huang
      Pages 157-170

  3. Gene Therapy Approaches

    1. Front Matter

      Pages 171-171
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    2. Oncogenes, Tumor Suppressor Genes and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy

      • Lidong Zhang, Bingliang Fang
      Pages 173-184

    3. Gene Silencing Therapy Against Cancer

      • Chao-Zhong Song
      Pages 185-196

    4. Tumor Targeting-Retargeted Adenovirus

      • Masato Yamamoto, David T. Curiel
      Pages 197-212

    5. Oncolytic Herpes Simplex for Gene Therapy in Preclinical and Clinical Trials

      • Richard H. Pin, Maura Reinblatt, Yuman Fong, William R. Jarnagin
      Pages 213-222

    6. Cytokine Gene Therapy for Genitourinary Cancer

      • Terry L. Timme, Tetsuo Fujita, Hongyu Wang, Koji Naruishi, Dov Kadmon, Robert J. Amato et al.
      Pages 223-241

    7. Combination of Gene Therapy with Radiation

      • Anupama Munshi, Raymond E. Meyn
      Pages 243-256

    8. Gene Transfer for Chemoprotection and Enrichment of Hematopoietic Stem Cells

      • Justin C. Roth, Stanton L. Gerson
      Pages 257-279

    9. Nonviral Genetic Vaccines for Cancer

      • Steven R. Little, Daniel G. Anderson, Robert S. Langer
      Pages 281-300
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Keywords

About this book

The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes. Unlike the treatment of genetic defects, where expr- sion of the corrected gene needs to be strong, permanent and, sometimes regulated, tactics to treat tumors can be based on temporary and locally limited effects. In addition, cancer cells have different properties than normal cells and this allows for targeting gene therapy to specific cells, a major advantage over current antitumor therapies, which are also toxic to normal cells and tissues.

Reviews

From the reviews:

"The book is divided into 3 sections. … this book is informative and provides a comprehensive review of the advances and limitations of cancer gene therapy. … Overall, the book provides enjoyable and instructive reading material. I highly recommend this book to scientists as well as clinicians as a reference source for cancer gene therapy. Readers would benefit from this excellent reading material, whether they are relatively new to this subspecialty or are actively working within the field of cancer gene therapy." (Prem Seth, JAMA, Vol. 299 (11), 2008)

"Gene Therapy for Cancer … covers the current technologies of cancer gene therapy as well as the difficult task of applying these in clinical trials. … The book also benefits through its helpful tables, drawings and illustrations. … Gene Therapy for Cancer provides a good overview of currently available techniques for cancer gene therapy and their limitations and potential for clinical applications. The book is a useful addition to the library of both researchers and clinicians working in the field." (S. Schepelmann and C. J. Springer, British Journal of Cancer, Vol. 98 (3), 2008)

“This new volume in Humana’s series is written for oncologists, hematologists, cancer researchers, geneticists.” (Tumori, Vol. 93, 2007)

Editors and Affiliations

  • The University of Texas M. D. Anderson Cancer Center, Houston

    Kelly K. Hunt, Stephen G. Swisher

  • Inselspital Bern, University of Bern, Bern, Switzerland

    Stephan A. Vorburger

Bibliographic Information

  • Book Title: Gene Therapy for Cancer

  • Editors: Kelly K. Hunt, Stephan A. Vorburger, Stephen G. Swisher

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-222-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2007

  • Hardcover ISBN: 978-1-58829-472-2Published: 02 February 2007

  • Softcover ISBN: 978-1-61737-590-3Published: 09 December 2010

  • eBook ISBN: 978-1-59745-222-9Published: 26 October 2007

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XII, 469

  • Number of Illustrations: 69 b/w illustrations, 16 illustrations in colour

  • Topics: Oncology, Hematology, Cancer Research

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