The Genetics of Male Infertility

1. Front Matter

   Pages i-xv

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2. Methods and Tools for the Study

   1. Front Matter

      Pages 2-2

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   2. The Genetics of Male Infertility in the Era of Genomics

      • Douglas T. Carrell

      Pages 3-27

   3. The Use of cDNA Libraries to Demonstrate a Linkage Between Transcription and Translation in Male Germ Cells

      • Norman B. Hecht

      Pages 29-35

   4. Considerations When Using Array Technologies for Male Factor Assessment

      • Adrian E. Platts, David J. Dix, Stephen A. Krawetz

      Pages 37-54

   5. Microarray Analysis of a Large Number of Single-Nucleotide Polymorphisms in Individual Human Spermatozoa

      • Honghua Li, Xiangfeng Cui, Danielle M. Greenawalt, Guohong Hu, Nyam-Osor Chimge, Sreemanta Pramanik et al.

      Pages 55-76

   6. Physiological and Proteomic Approaches to Understanding Human Sperm Function

      • Sarah J. Conner, Linda Lefièvre, Jackson Kirkman-Brown, Gisela S. M. Machado-Oliveira, Frank Michelangeli, Stephen J. Publicover et al.

      Pages 77-97

   7. Genetics of Idiopathic Male Infertility

      • Angshumoy Roy, Yi-Nan Lin, Martin M. Matzuk

      Pages 99-111

3. Meiosis and Errors of Meiosis

   1. Front Matter

      Pages 113-113

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   2. The Immunocytogenetics of Human Male Meiosis

      • Daniel Topping, Petrice Brown, Terry Hassold

      Pages 115-128

   3. The Clinical Relevance of Sperm Aneuploidy

      • Renee H. Martin

      Pages 129-144

   4. DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility

      • Francesca K. E. Gordon, Dolores J. Lamb

      Pages 145-163

4. The Y Chromosome, Development Spermatogenesis, and Sperm Maturation

   1. Front Matter

      Pages 165-165

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   2. Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis

      • Mark S. Fox, Renee A. Reijo Pera

      Pages 167-184

   3. The Genetics of Cryptorchidism

      • Alexander I. Agoulnik, Shu Feng

      Pages 185-198

   4. The Chromatoid Body and microRNA Pathways in Male Germ Cells

      • Martti Parvinen, Noora Kotaja, Durga Prasad Mishra, Paolo Sassone-Corsi

      Pages 199-209

   5. Sperm Maturation in the Epididymis

      • Gail A. Cornwall, Hans H. von Horsten

      Pages 211-231

5. Clinical Applications of the Study of the Genetics of Male Infertility

   1. Front Matter

      Pages 232-232

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   2. The Structure of the Y Chromosome and Its Role in Male Infertility

      • Leslie Ayensu-Coker, Colin Bishop, Jan Rohozinski

      Pages 233-238

   3. Y Chromosome Microdeletions and Haplotypes

      • Ken McElreavey, Celia Ravel, Brahim El Houate, Jacqueline Mandelbaum, Sandra Chantot-Bastaraud, Jean-Pierre Siffroi

      Pages 239-249

Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.
This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms.
Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

• Chromosom
• DNA
• Genetic abnormalities
• In silico technologies
• In vitro fertilization
• Intracytoplasmic injection
• SNP
• Single Nucleotide Polymorphism
• Termination
• genetics
• infertility
• transcription
• translation

• Departments of Surgery (Urology), Obstetrics and Gynecology, and Physiology, University of Utah School of Medicine, Salt Lake City

  Douglas T. Carrell

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